ENSDARG00000060841


Danio rerio

Features
Gene ID: ENSDARG00000060841
  
Biological name :pik3c2a
  
Synonyms : phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha / pik3c2a
  
Possible biological names infered from orthology : O00443
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 27000850
Gene end: 27078219
  
Corresponding Affymetrix probe sets: Dr.12319.1.A1_at (Zebrafish Array)   Dr.2475.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000146936
Ensembl peptide - ENSDARP00000080566
Ensembl peptide - ENSDARP00000120821
NCBI entrez gene - 571356     See in Manteia.
swissprot - F6NMW9
swissprot - Q1L913
ZFIN ID - ZDB-GENE-030328-39
Ensembl - ENSDARG00000060841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIK3C2AENSGALG00000006121Gallus gallus
 O00443ENSG00000011405Homo sapiens
 Pik3c2aENSMUSG00000030660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pik3c2b / phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta / O00750*ENSDARG0000008692740
pik3c2g / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma / O75747*ENSDARG0000009980321
pik3cg / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma / P48736* / Q9JHG7* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform *ENSDARG0000001775716
si:rp71-17i16.5ENSDARG0000003752715
pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta / O00329*ENSDARG0000000325015
pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *ENSDARG0000007525315
zgc:158659ENSDARG0000006059715
pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *ENSDARG0000007545614
pik3c3 / phosphatidylinositol 3-kinase, catalytic subunit type 3 / Q6PF93* / Q8NEB9*ENSDARG0000005482912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR001683  Phox homologous domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048268 clathrin coat assembly IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001057 intersegmental vein intersegmental vein decreased length , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel angiogenesis process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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