ENSG00000110497


Homo sapiens

Features
Gene ID: ENSG00000110497
  
Biological name :AMBRA1
  
Synonyms : AMBRA1 / autophagy and beclin 1 regulator 1 / Q9C0C7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p11.2
Gene start: 46396414
Gene end: 46594125
  
Corresponding Affymetrix probe sets: 219141_s_at (Human Genome U133 Plus 2.0 Array)   234236_at (Human Genome U133 Plus 2.0 Array)   234237_s_at (Human Genome U133 Plus 2.0 Array)   52731_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433372
Ensembl peptide - ENSP00000431926
Ensembl peptide - ENSP00000433945
Ensembl peptide - ENSP00000434895
Ensembl peptide - ENSP00000318313
Ensembl peptide - ENSP00000415327
Ensembl peptide - ENSP00000431486
NCBI entrez gene - 55626     See in Manteia.
OMIM - 611359
RefSeq - XM_017018008
RefSeq - NM_001300731
RefSeq - NM_017749
RefSeq - XM_005253009
RefSeq - XM_005253011
RefSeq - XM_005253014
RefSeq - XM_006718259
RefSeq - XM_006718260
RefSeq - XM_017018007
RefSeq - NM_001267782
RefSeq - NM_001267783
RefSeq Peptide - NP_001287660
RefSeq Peptide - NP_060219
RefSeq Peptide - NP_001254711
RefSeq Peptide - NP_001254712
swissprot - Q9C0C7
swissprot - H0YE34
swissprot - E9PL55
swissprot - A0A075B6T1
Ensembl - ENSG00000110497
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ambra1aENSDARG00000008322Danio rerio
 ambra1bENSDARG00000039878Danio rerio
 AMBRA1ENSGALG00000008358Gallus gallus
 A2AH22ENSMUSG00000040506Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000422 autophagy of mitochondrion IGI
 biological_processGO:0000423 mitophagy IMP
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0098780 response to mitochondrial depolarisation IGI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane NAS
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / reaction / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / complex / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / reaction
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / reaction / complex
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / reaction / complex
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex / reaction






 

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