ENSG00000080546


Homo sapiens

Features
Gene ID: ENSG00000080546
  
Biological name :SESN1
  
Synonyms : Q9Y6P5 / SESN1 / sestrin 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q21
Gene start: 108986437
Gene end: 109094819
  
Corresponding Affymetrix probe sets: 218346_s_at (Human Genome U133 Plus 2.0 Array)   236512_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306734
Ensembl peptide - ENSP00000349061
Ensembl peptide - ENSP00000393762
NCBI entrez gene - 27244     See in Manteia.
OMIM - 606103
RefSeq - NM_001199934
RefSeq - NM_001199933
RefSeq - NM_014454
RefSeq Peptide - NP_001186862
RefSeq Peptide - NP_001186863
RefSeq Peptide - NP_055269
swissprot - Q9Y6P5
Ensembl - ENSG00000080546
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sesn1ENSDARG00000020693Danio rerio
 SESN1ENSGALG00000015286Gallus gallus
 Sesn1ENSMUSG00000038332Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SESN3 / P58005 / sestrin 3ENSG0000014921253
SESN2 / P58004 / sestrin 2ENSG0000013076649


Protein motifs (from Interpro)
Interpro ID Name
 IPR006730  Sestrin
 IPR029032  AhpD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0042149 cellular response to glucose starvation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:0098869 cellular oxidant detoxification IMP
 biological_processGO:1901031 regulation of response to reactive oxygen species IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling IMP
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0061700 GATOR2 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA
 molecular_functionGO:0070728 leucine binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction / complex
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction / complex
 ENSG00000117450 PRDX1 / Q06830 / peroxiredoxin 1  / reaction / complex
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / complex / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction / complex
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / complex / reaction






 

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