ENSMUSG00000038332


Mus musculus

Features
Gene ID: ENSMUSG00000038332
  
Biological name :Sesn1
  
Synonyms : P58006 / Sesn1 / Sestrin-1
  
Possible biological names infered from orthology : Q9Y6P5
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B2
Gene start: 41809935
Gene end: 41908424
  
Corresponding Affymetrix probe sets: 10362811 (MoGene1.0st)   1433711_s_at (Mouse Genome 430 2.0 Array)   1438931_s_at (Mouse Genome 430 2.0 Array)   1444376_at (Mouse Genome 430 2.0 Array)   1454699_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043034
Ensembl peptide - ENSMUSP00000097515
NCBI entrez gene - 140742     See in Manteia.
MGI - MGI:2155278
RefSeq - NM_001013370
RefSeq - NM_001162908
RefSeq Peptide - NP_001013388
RefSeq Peptide - NP_001156380
swissprot - P58006
swissprot - E9PXR3
Ensembl - ENSMUSG00000038332
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sesn1ENSDARG00000020693Danio rerio
 SESN1ENSGALG00000015286Gallus gallus
 SESN1ENSG00000080546Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sesn3 / Q9CYP7 / sestrin 3 / P58005*ENSMUSG0000003200952
Sesn2 / P58043 / Sestrin-2 / P58004*ENSMUSG0000002889350


Protein motifs (from Interpro)
Interpro ID Name
 IPR006730  Sestrin
 IPR029032  AhpD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0034198 cellular response to amino acid starvation ISO
 biological_processGO:0042149 cellular response to glucose starvation ISO
 biological_processGO:0051896 regulation of protein kinase B signaling IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IMP
 biological_processGO:0072593 reactive oxygen species metabolic process ISS
 biological_processGO:0098869 cellular oxidant detoxification ISO
 biological_processGO:1901031 regulation of response to reactive oxygen species IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling ISO
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0061700 GATOR2 complex ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA
 molecular_functionGO:0070728 leucine binding ISS


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0013762 abnormal effector T cell number 
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / complex / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction / complex
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / complex / reaction
 ENSMUSG00000028691 Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*  / reaction / complex
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction / complex
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / complex / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / complex / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction / complex






 

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