ENSMUSG00000032009


Mus musculus

Features
Gene ID: ENSMUSG00000032009
  
Biological name :Sesn3
  
Synonyms : Q9CYP7 / Sesn3 / sestrin 3
  
Possible biological names infered from orthology : P58005
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 14275067
Gene end: 14333101
  
Corresponding Affymetrix probe sets: 10583242 (MoGene1.0st)   1449303_at (Mouse Genome 430 2.0 Array)   1453313_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034507
Ensembl peptide - ENSMUSP00000146784
Ensembl peptide - ENSMUSP00000146362
NCBI entrez gene - 75747     See in Manteia.
MGI - MGI:1922997
RefSeq - NM_030261
RefSeq Peptide - NP_084537
swissprot - A0A140LIE1
swissprot - A0A0J9YMZ5
swissprot - A2RSF4
swissprot - Q9CYP7
Ensembl - ENSMUSG00000032009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sesn3ENSDARG00000015822Danio rerio
 ENSGALG00000017204Gallus gallus
 SESN3ENSG00000149212Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sesn1 / P58006 / Sestrin-1 / Q9Y6P5*ENSMUSG0000003833259
Sesn2 / P58043 / Sestrin-2 / P58004*ENSMUSG0000002889352


Protein motifs (from Interpro)
Interpro ID Name
 IPR006730  Sestrin
 IPR029032  AhpD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0038203 TORC2 signaling IMP
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IMP
 biological_processGO:0051896 regulation of protein kinase B signaling IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IMP
 biological_processGO:1901031 regulation of response to reactive oxygen species IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0031932 TORC2 complex IDA
 cellular_componentGO:0061700 GATOR2 complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg,Sesn3tm1a(EUCOMM)Wtsi/Sesn3tm1a(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg,Sesn3tm1a(EUCOMM)Wtsi/Sesn3tm1a(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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