ENSMUSG00000028893


Mus musculus

Features
Gene ID: ENSMUSG00000028893
  
Biological name :Sesn2
  
Synonyms : P58043 / Sesn2 / Sestrin-2
  
Possible biological names infered from orthology : P58004
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 132492032
Gene end: 132510501
  
Corresponding Affymetrix probe sets: 10516932 (MoGene1.0st)   1425139_at (Mouse Genome 430 2.0 Array)   1451599_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030724
NCBI entrez gene - 230784     See in Manteia.
MGI - MGI:2651874
RefSeq - NM_144907
RefSeq Peptide - NP_659156
swissprot - P58043
Ensembl - ENSMUSG00000028893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sesn2ENSDARG00000070012Danio rerio
 SESN2ENSGALG00000037603Gallus gallus
 SESN2ENSG00000130766Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sesn1 / P58006 / Sestrin-1 / Q9Y6P5*ENSMUSG0000003833257
Sesn3 / Q9CYP7 / sestrin 3 / P58005*ENSMUSG0000003200954


Protein motifs (from Interpro)
Interpro ID Name
 IPR006730  Sestrin
 IPR029032  AhpD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006635 fatty acid beta-oxidation IGI
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0032042 mitochondrial DNA metabolic process IMP
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0042593 glucose homeostasis IGI
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0046323 glucose import IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071233 cellular response to leucine IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1901031 regulation of response to reactive oxygen species IEA
 biological_processGO:1902010 negative regulation of translation in response to endoplasmic reticulum stress IMP
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 biological_processGO:1904504 positive regulation of lipophagy IMP
 biological_processGO:1990253 cellular response to leucine starvation IEA
 biological_processGO:2000479 regulation of cAMP-dependent protein kinase activity IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IDA
 cellular_componentGO:0031932 TORC2 complex IDA
 cellular_componentGO:0061700 GATOR2 complex IEA
 cellular_componentGO:1990316 Atg1/ULK1 kinase complex IEA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016684 oxidoreductase activity, acting on peroxide as acceptor IEA
 molecular_functionGO:0032542 sulfiredoxin activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA
 molecular_functionGO:0070728 leucine binding IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg,Sesn3tm1a(EUCOMM)Wtsi/Sesn3tm1a(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg,Sesn3tm1a(EUCOMM)Wtsi/Sesn3tm1a(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg,Sesn3tm1a(EUCOMM)Wtsi/Sesn3tm1a(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrc-Bc3/Tyrc-Bc3
Genetic Background: SELH/Bc

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0011807 decreased lung fibroblast proliferation "reduction in the expansion rate of a lung fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Tyrc-Bc3/Tyrc-Bc3
Genetic Background: SELH/Bc

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Tyrc-Bc3/Tyrc-Bc3
Genetic Background: SELH/Bc

 MP:0014174 decreased fatty acid beta-oxidation "decreased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt,Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction / complex
 ENSMUSG00000028691 Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*  / reaction / complex
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction / complex
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction / complex
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction / complex
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / complex / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / complex / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction / complex






 

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