ENSMUSG00000028691


Mus musculus

Features
Gene ID: ENSMUSG00000028691
  
Biological name :Prdx1
  
Synonyms : P35700 / Peroxiredoxin-1 / Prdx1
  
Possible biological names infered from orthology : Q06830
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 116685544
Gene end: 116700822
  
Corresponding Affymetrix probe sets: 10436048 (MoGene1.0st)   10507328 (MoGene1.0st)   1416000_a_at (Mouse Genome 430 2.0 Array)   1433866_x_at (Mouse Genome 430 2.0 Array)   1434731_x_at (Mouse Genome 430 2.0 Array)   1436691_x_at (Mouse Genome 430 2.0 Array)   1437014_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102078
Ensembl peptide - ENSMUSP00000119794
Ensembl peptide - ENSMUSP00000117007
Ensembl peptide - ENSMUSP00000114159
Ensembl peptide - ENSMUSP00000030454
NCBI entrez gene - 18477     See in Manteia.
MGI - MGI:99523
RefSeq - NM_011034
RefSeq Peptide - NP_035164
swissprot - B1AXW5
swissprot - B1AXW4
swissprot - B1AXW6
swissprot - P35700
Ensembl - ENSMUSG00000028691
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx1ENSDARG00000058734Danio rerio
 PRDX1ENSGALG00000010243Gallus gallus
 PRDX1ENSG00000117450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdx2 / Q61171 / Peroxiredoxin-2 / P32119*ENSMUSG0000000516174
Prdx4 / O08807 / peroxiredoxin 4 / Q13162*ENSMUSG0000002528966
Prdx3 / P20108 / Thioredoxin-dependent peroxide reductase, mitochondrial / P30048* / peroxiredoxin 3*ENSMUSG0000002499761
Gm5225 / PRDX2* / P32119* / peroxiredoxin 2*ENSMUSG0000009526631


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IMP
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0019430 removal of superoxide radicals IMP
 biological_processGO:0030101 natural killer cell activation ISO
 biological_processGO:0032872 regulation of stress-activated MAPK cascade IMP
 biological_processGO:0034101 erythrocyte homeostasis IMP
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IMP
 biological_processGO:0042744 hydrogen peroxide catabolic process ISO
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0004601 peroxidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008379 thioredoxin peroxidase activity ISO
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1flro/Prdx1flro
Genetic Background: C57BL/10JAnu-Prdx1flro/Apb

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prdx1flro/Prdx1flro
Genetic Background: C57BL/10JAnu-Prdx1flro/Apb

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003430 islet cell adenoma "a benign epithelial neoplasm with a glandular organization present in islet cells of the pancreas" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0008038 abnormal NK T cell number "deviation from the normal number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008850 increased hemoglobin concentration distribution width "higher than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations; high HDW is indicative of some types of anemia/thalassemia" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0009321 histiocytic sarcoma 
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / reaction
 ENSMUSG00000028691 Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*  / complex
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction
 ENSMUSG00000028893 Sesn2 / P58043 / Sestrin-2 / P58004*  / reaction / complex
 ENSMUSG00000038332 Sesn1 / P58006 / Sestrin-1 / Q9Y6P5*  / reaction / complex
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / reaction






 

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