ENSMUSG00000025583


Mus musculus

Features
Gene ID: ENSMUSG00000025583
  
Biological name :Rptor
  
Synonyms : regulatory associated protein of MTOR, complex 1 / Rptor
  
Possible biological names infered from orthology : Q8N122
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 119602905
Gene end: 119899576
  
Corresponding Affymetrix probe sets: 10383245 (MoGene1.0st)   1430784_a_at (Mouse Genome 430 2.0 Array)   1434619_at (Mouse Genome 430 2.0 Array)   1458472_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125503
Ensembl peptide - ENSMUSP00000125293
Ensembl peptide - ENSMUSP00000125667
Ensembl peptide - ENSMUSP00000026671
Ensembl peptide - ENSMUSP00000124366
Ensembl peptide - ENSMUSP00000124886
NCBI entrez gene - 74370     See in Manteia.
MGI - MGI:1921620
RefSeq - XM_006534363
RefSeq - NM_001306081
RefSeq - NM_028898
RefSeq - XM_006534361
RefSeq - XM_006534362
RefSeq Peptide - NP_083174
RefSeq Peptide - NP_001293010
swissprot - F6U5L3
swissprot - F7B6I3
swissprot - F7BQS0
swissprot - E9PXZ5
swissprot - F7CN67
swissprot - A2ACM0
Ensembl - ENSMUSG00000025583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rptorENSDARG00000098726Danio rerio
 RPTORENSGALG00000034210Gallus gallus
 RPTORENSG00000141564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000357  HEAT repeat
 IPR001680  WD40 repeat
 IPR004083  Regulatory associated protein of TOR
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR017986  WD40-repeat-containing domain
 IPR029347  Raptor, N-terminal CASPase-like domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0038202 TORC1 signaling IEA
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071233 cellular response to leucine IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031931 TORC1 complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0001030 RNA polymerase III type 1 promoter DNA binding IEA
 molecular_functionGO:0001031 RNA polymerase III type 2 promoter DNA binding IEA
 molecular_functionGO:0001032 RNA polymerase III type 3 promoter DNA binding IEA
 molecular_functionGO:0001156 TFIIIC-class transcription factor binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptortm1Rueg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Rptortm1.1Dmsa/Rptortm1.1Dmsa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rptortm1.1Dmsa/Rptortm1.1Dmsa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rptortm1.1Dmsa/Rptortm1.1Dmsa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Rictortm1Rueg/Rictortm1Rueg,Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rictortm1Rueg/Rictortm1Rueg,Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Rictortm1Rueg/Rictortm1Rueg,Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Rictortm1Rueg/Rictortm1Rueg,Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Rptortm1.1Dmsa/Rptortm1.1Dmsa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptortm1Rueg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004130 abnormal muscle cell glucose uptake "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptortm1Rueg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(Wnt7b)Flng/Gt(ROSA)26Sor+,Rptortm1Rueg/Rptor+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Rptortm2b(EUCOMM)Wtsi/Rptortm2b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rptortm2b(EUCOMM)Wtsi/H

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Rptortm1Rueg/Rptortm1Rueg,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: RictorGt(RRR347)Byg/RictorGt(RRR347)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Rptortm2b(EUCOMM)Wtsi/Rptortm2b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rptortm2b(EUCOMM)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Rptortm2b(EUCOMM)Wtsi/Rptortm2b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rptortm2b(EUCOMM)Wtsi/H

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr