ENSG00000173334


Homo sapiens

Features
Gene ID: ENSG00000173334
  
Biological name :TRIB1
  
Synonyms : Q96RU8 / TRIB1 / tribbles pseudokinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.13
Gene start: 125430321
Gene end: 125438405
  
Corresponding Affymetrix probe sets: 202241_at (Human Genome U133 Plus 2.0 Array)   235641_at (Human Genome U133 Plus 2.0 Array)   239818_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312150
Ensembl peptide - ENSP00000429063
Ensembl peptide - ENSP00000428879
NCBI entrez gene - 10221     See in Manteia.
OMIM - 609461
RefSeq - NM_001282985
RefSeq - NM_025195
RefSeq Peptide - NP_001269914
RefSeq Peptide - NP_079471
swissprot - E5RFH4
swissprot - Q96RU8
Ensembl - ENSG00000173334
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trib1ENSDARG00000110963Danio rerio
 TRIB1ENSGALG00000036456Gallus gallus
 Trib1ENSMUSG00000032501Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIB2 / Q92519 / tribbles pseudokinase 2ENSG0000007157555
TRIB3 / Q96RU7 / tribbles pseudokinase 3ENSG0000010125543
NUAK1 / O60285 / NUAK family kinase 1ENSG0000007459026
NUAK2 / Q9H093 / NUAK family kinase 2ENSG0000016354526
STK40 / Q8N2I9 / serine/threonine kinase 40ENSG0000019618223
P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2ENSG0000016240922
PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1ENSG0000013235620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR024104  Pseudokinase tribbles family/serine-threonine-protein kinase 40
 IPR024105  Tribbles homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0007254 JNK cascade IMP
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IMP
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0043405 regulation of MAP kinase activity IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0045645 positive regulation of eosinophil differentiation IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045659 negative regulation of neutrophil differentiation IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISS
 molecular_functionGO:0055106 ubiquitin-protein transferase regulator activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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