ENSMUSG00000045038


Mus musculus

Features
Gene ID: ENSMUSG00000045038
  
Biological name :Prkce
  
Synonyms : P16054 / Prkce / protein kinase C, epsilon
  
Possible biological names infered from orthology : Q02156
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 86167785
Gene end: 86657919
  
Corresponding Affymetrix probe sets: 10447294 (MoGene1.0st)   1437860_at (Mouse Genome 430 2.0 Array)   1437861_s_at (Mouse Genome 430 2.0 Array)   1449956_at (Mouse Genome 430 2.0 Array)   1452878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094873
Ensembl peptide - ENSMUSP00000094874
Ensembl peptide - ENSMUSP00000138615
NCBI entrez gene - 18754     See in Manteia.
MGI - MGI:97599
RefSeq - XM_017317328
RefSeq - NM_011104
RefSeq - XM_006523833
RefSeq Peptide - NP_035234
swissprot - Q8C944
swissprot - P16054
Ensembl - ENSMUSG00000045038
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkceaENSDARG00000003008Danio rerio
 prkcebENSDARG00000069928Danio rerio
 PRKCEENSGALG00000010000Gallus gallus
 PRKCEENSG00000171132Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110860
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096541
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288940
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194840
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677839
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881638
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764331
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905331
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969925
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172925
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405624
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591524
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997023
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027274  Protein kinase C, epsilon
 IPR034669  Novel protein kinase C epsilon, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002281 macrophage activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007635 chemosensory behavior TAS
 biological_processGO:0010634 positive regulation of epithelial cell migration ISO
 biological_processGO:0010763 positive regulation of fibroblast migration IMP
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IMP
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035641 locomotory exploration behavior IGI
 biological_processGO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043278 response to morphine IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050996 positive regulation of lipid catabolic process IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0070257 positive regulation of mucus secretion IMP
 biological_processGO:0071361 cellular response to ethanol IGI
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0090303 positive regulation of wound healing ISS
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 biological_processGO:2001031 positive regulation of cellular glucuronidation ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003785 actin monomer binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004697 protein kinase C activity ISO
 molecular_functionGO:0004699 calcium-independent protein kinase C activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008047 enzyme activator activity ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030546 receptor activator activity IDA
 molecular_functionGO:0035276 ethanol binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IPI


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Acvrl1tm1Spo/Acvrl1tm1Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0011077 decreased macrophage nitric oxide production "reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlx2tm1Fsh/Dlx2tm1Fsh
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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