ENSMUSG00000026778


Mus musculus

Features
Gene ID: ENSMUSG00000026778
  
Biological name :Prkcq
  
Synonyms : Prkcq / protein kinase C, theta / Q02111
  
Possible biological names infered from orthology : Q04759
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 11172108
Gene end: 11301222
  
Corresponding Affymetrix probe sets: 10469255 (MoGene1.0st)   1426044_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100035
Ensembl peptide - ENSMUSP00000028118
NCBI entrez gene - 18761     See in Manteia.
MGI - MGI:97601
RefSeq - XM_006497398
RefSeq - XM_011238965
RefSeq - NM_008859
RefSeq Peptide - NP_032885
swissprot - Q02111
swissprot - F8WGT6
swissprot - A6H667
Ensembl - ENSMUSG00000026778
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcqENSDARG00000034173Danio rerio
 PRKCQENSGALG00000034970Gallus gallus
 PRKCQENSG00000065675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194861
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503841
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110839
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096539
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881638
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288938
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905328
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764328
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172925
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969925
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997025
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405624
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591523
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027264  Protein kinase C, theta
 IPR034668  Novel protein kinase C theta, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IDA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase ISO
 biological_processGO:0032740 positive regulation of interleukin-17 production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway ISS
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051973 positive regulation of telomerase activity ISO
 biological_processGO:0060326 cell chemotaxis ISO
 biological_processGO:0070233 negative regulation of T cell apoptotic process ISS
 biological_processGO:0090330 regulation of platelet aggregation IMP
 biological_processGO:1904355 positive regulation of telomere capping ISO
 biological_processGO:2000318 positive regulation of T-helper 17 type immune response IMP
 biological_processGO:2000570 positive regulation of T-helper 2 cell activation IMP
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Downstream TCR signaling
FCERI mediated NF-kB activation
Netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/10

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Ikbkbtm2Mka/Ikbkbtm2Mka,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Prkcqtm1Litt/Prkcq+
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0001267 enlarged chest "wider diameter, or distended chest cavity" [J:18048]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/10

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: A/?,Tyrc/Tyrem6Ove
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ikbkbtm2Mka/Ikbkbtm2Mka,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: ABJ/LeJ-Prkcqrpea1/Boc

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/10

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcdh15m5Btlr/Pcdh15m5Btlr
Genetic Background: C57BL/6J-Pcdh15m5Btlr

Allelic Composition: Prkcqm2Btlr/Prkcqm2Btlr
Genetic Background: C57BL/6J-Prkcqm2Btlr

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tmod2tm2Hzo/Tmod2tm2Hzo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/10

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm2Mka/Ikbkbtm2Mka,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: ABJ/LeJ-Prkcqrpea1/Boc

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0004130 abnormal muscle cell glucose uptake "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004185 abnormal adipocyte glucose uptake "anomaly in the ability of adipocytes to take in glucose" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator ""]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/10

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptcratm1.1Shoy/Ptcratm1.1Shoy
Genetic Background: involves: C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tcratm1Mom/Tcratm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: ABJ/LeJ-Prkcqrpea1/Boc

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129 * BALB/c * C3H * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0005548 retinal pigment epithelium atrophy "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

 MP:0006237 abnormal choroid vasculature "malformation of the blood vessels of the choroid" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129 * BALB/c * C3H * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: ABJ/LeJ-Prkcqrpea1/Boc

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129 * BALB/c * C3H * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(LCKprBCL2L1)12Sjk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tcratm1Mom/Tcratm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008747 abnormal T cell anergy "any anomaly in the process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction" [GO:0002870]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0009274 buphthalmos "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: ABJ/LeJ-Prkcqrpea1/Boc

Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129 * BALB/c * C3H * C57BL/6

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129 * BALB/c * C3H * C57BL/6

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/10

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Pcdh15m5Btlr/Pcdh15m5Btlr
Genetic Background: C57BL/6J-Pcdh15m5Btlr

Allelic Composition: Prkcqm2Btlr/Prkcqm2Btlr
Genetic Background: C57BL/6J-Prkcqm2Btlr

 MP:0020442 serous retinal detachment "a retinal detachment resulting from accumulation of fluid between the retina and retinal pigment epithelium in the absence of a retinal tear" [doi: 10.1167/iovs.15-17495]
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Allelic Composition: Pde6brd1/Pde6brd1,Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1 Pde6brd1/Boc

Allelic Composition: Prkcqrpea1/Prkcqrpea1
Genetic Background: B6.ABJ-Prkcqrpea1/Boc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000052397 Ezr / Ezrin / P26040 / P15311*  / reaction
 ENSMUSG00000036526 Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*  / reaction / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction / complex
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / reaction / complex
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction






 

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