ENSMUSG00000036526


Mus musculus

Features
Gene ID: ENSMUSG00000036526
  
Biological name :Card11
  
Synonyms : Card11 / Caspase recruitment domain-containing protein 11 / Q8CIS0
  
Possible biological names infered from orthology : caspase recruitment domain family member 11 / Q9BXL7
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 140872990
Gene end: 141000582
  
Corresponding Affymetrix probe sets: 10535282 (MoGene1.0st)   1430257_at (Mouse Genome 430 2.0 Array)   1435996_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082941
NCBI entrez gene - 108723     See in Manteia.
MGI - MGI:1916978
RefSeq - NM_175362
RefSeq Peptide - NP_780571
swissprot - Q8CIS0
Ensembl - ENSMUSG00000036526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 card11ENSDARG00000052741Danio rerio
 CARD11ENSGALG00000004398Gallus gallus
 CARD11ENSG00000198286Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Card10 / P58660 / Caspase recruitment domain-containing protein 10 / Q9BWT7* / caspase recruitment domain family member 10*ENSMUSG0000003317033
Card14 / Q99KF0 / Caspase recruitment domain-containing protein 14 / Q9BXL6* / caspase recruitment domain family member 14*ENSMUSG0000001348327
Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*ENSMUSG0000002692819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR011029  Death-like domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033538  Caspase recruitment domain-containing protein 11
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002377 immunoglobulin production IMP
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0038202 TORC1 signaling IEA
 biological_processGO:0042100 B cell proliferation IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045061 thymic T cell selection IMP
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IMP
 biological_processGO:0045577 regulation of B cell differentiation IMP
 biological_processGO:0045580 regulation of T cell differentiation IMP
 biological_processGO:0046649 lymphocyte activation IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0070970 interleukin-2 secretion IMP
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032449 CBM complex IEA
 cellular_componentGO:0042101 T cell receptor complex IEA
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050700 CARD domain binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Tbx15de/Tbx15de
Genetic Background: STOCK J

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx15de/Tbx15de
Genetic Background: STOCK J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

Allelic Composition: Card11M2Btlr/Card11M2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Card11M4Btlr/Card11M4Btlr
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Card11M5Btlr/Card11M5Btlr
Genetic Background: C57BL/6J-Card11M5Btlr

Allelic Composition: Card11M5Btlr/Card11+
Genetic Background: C57BL/6J-Card11M5Btlr

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

Allelic Composition: Card11tm1.1Litt/Card11tm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Card11tm1.1Litt/Card11tm1.1Litt,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx15de/Tbx15de
Genetic Background: STOCK J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0003454 erythroderma "exfoliation and widespread, intense reddening of the skin due to inflammatory skin disease" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95549]
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Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11M5Btlr/Card11M5Btlr
Genetic Background: C57BL/6J-Card11M5Btlr

Allelic Composition: Card11M5Btlr/Card11+
Genetic Background: C57BL/6J-Card11M5Btlr

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Atp2b2m1Btlr/Atp2b2m1Btlr
Genetic Background: C57BL/6J-Atp2b2m1Btlr

Allelic Composition: Card11M5Btlr/Card11M5Btlr
Genetic Background: C57BL/6J-Card11M5Btlr

Allelic Composition: Card11M5Btlr/Card11+
Genetic Background: C57BL/6J-Card11M5Btlr

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Card11M4Btlr/Card11M4Btlr
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Card11M4Btlr/Card11M4Btlr
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0008203 absent B-1a cells "absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008213 absent immature B cells "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008397 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology "any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Adra2atm1Bkk/Adra2atm1Bkk,Adra2ctm1Gsb/Adra2ctm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

Allelic Composition: Card11tm1Vmd/Card11tm1Vmd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0008627 decreased circulating interleukin-5 level "reduction in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6

 MP:0008686 abnormal interleukin-2 secretion "anomaly in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Card11m1Btlr/Card11m1Btlr
Genetic Background: C57BL/6J-Card11m1Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Card11M4Btlr/Card11M4Btlr
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Card11M5Btlr/Card11M5Btlr
Genetic Background: C57BL/6J-Card11M5Btlr

Allelic Composition: Card11M5Btlr/Card11+
Genetic Background: C57BL/6J-Card11M5Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / reaction / complex
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction / complex
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / reaction / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction / complex
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction
 ENSMUSG00000036526 Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*  / - / reaction / complex






 

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