ENSMUSG00000026928


Mus musculus

Features
Gene ID: ENSMUSG00000026928
  
Biological name :Card9
  
Synonyms : A2AIV8 / Card9 / Caspase recruitment domain-containing protein 9
  
Possible biological names infered from orthology : caspase recruitment domain family member 9 / Q9H257
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 26352176
Gene end: 26360918
  
Corresponding Affymetrix probe sets: 10480950 (MoGene1.0st)   10480956 (MoGene1.0st)   1428913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097876
Ensembl peptide - ENSMUSP00000028294
NCBI entrez gene - 332579     See in Manteia.
MGI - MGI:2685628
RefSeq - NM_001037747
RefSeq - XM_006498135
RefSeq - XM_017319060
RefSeq Peptide - NP_001032836
swissprot - A2AIV8
Ensembl - ENSMUSG00000026928
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 card9ENSDARG00000067672Danio rerio
 CARD9ENSGALG00000001889Gallus gallus
 CARD9ENSG00000187796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*ENSMUSG0000003652640
Card10 / P58660 / Caspase recruitment domain-containing protein 10 / Q9BWT7* / caspase recruitment domain family member 10*ENSMUSG0000003317036
Card14 / Q99KF0 / Caspase recruitment domain-containing protein 14 / Q9BXL6* / caspase recruitment domain family member 14*ENSMUSG0000001348326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0009620 response to fungus IMP
 biological_processGO:0032494 response to peptidoglycan IMP
 biological_processGO:0032495 response to muramyl dipeptide IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade ISO
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0042534 regulation of tumor necrosis factor biosynthetic process IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0045076 regulation of interleukin-2 biosynthetic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045408 regulation of interleukin-6 biosynthetic process IMP
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051607 defense response to virus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0050700 CARD domain binding IEA


Pathways (from Reactome)
Pathway description
CLEC7A (Dectin-1) signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0008691 decreased interleukin-23 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
Show

Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htttm2Msl/Htttm2Msl
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Card9tm1Tks/Card9tm1Tks
Genetic Background: B6.129-Card9tm1Tks

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000021948 Prkcd / P28867 / protein kinase C, delta / Q05655*  / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000026928 Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*  / - / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / complex / reaction
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / reaction / complex
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / reaction / complex
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction






 

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