ENSMUSG00000032688


Mus musculus

Features
Gene ID: ENSMUSG00000032688
  
Biological name :Malt1
  
Synonyms : Malt1 / Mucosa-associated lymphoid tissue lymphoma translocation / Q2TBA3
  
Possible biological names infered from orthology : MALT1 paracaspase / Q9UDY8
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 65430962
Gene end: 65478823
  
Corresponding Affymetrix probe sets: 10456296 (MoGene1.0st)   1445068_at (Mouse Genome 430 2.0 Array)   1456126_at (Mouse Genome 430 2.0 Array)   1456429_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048376
Ensembl peptide - ENSMUSP00000153585
NCBI entrez gene - 240354     See in Manteia.
MGI - MGI:2445027
RefSeq - XM_006525937
RefSeq - NM_172833
RefSeq Peptide - NP_766421
swissprot - Q2TBA3
Ensembl - ENSMUSG00000032688
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 malt1ENSDARG00000077768Danio rerio
 MALT1ENSGALG00000030063Gallus gallus
 MALT1ENSG00000172175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR011029  Death-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR029030  Caspase-like domain superfamily
 IPR033540  Mucosa-associated lymphoid tissue lymphoma translocation protein 1
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001923 B-1 B cell differentiation IMP
 biological_processGO:0002237 response to molecule of bacterial origin IEP
 biological_processGO:0002726 positive regulation of T cell cytokine production ISO
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling RCA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity ISO
 biological_processGO:0009620 response to fungus IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production ISO
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0042113 B cell activation IMP
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0045087 innate immune response IEP
 biological_processGO:0050852 T cell receptor signaling pathway ISO
 biological_processGO:0050856 regulation of T cell receptor signaling pathway IMP
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051168 nuclear export ISO
 biological_processGO:0051259 protein complex oligomerization ISO
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032449 CBM complex ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019209 kinase activator activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043621 protein self-association ISO


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
CLEC7A/inflammasome pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Tg(Mef2c-cre)2Blk/0
Genetic Background: Not Specified

Allelic Composition: Malt1m2Btlr/Malt1m2Btlr
Genetic Background: C57BL/6J-Malt1m2Btlr

Allelic Composition: Malt1m3Btlr/Malt1m3Btlr
Genetic Background: C57BL/6J-Malt1m3Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Tg(Mef2c-cre)2Blk/0
Genetic Background: Not Specified

Allelic Composition: Malt1m2Btlr/Malt1m2Btlr
Genetic Background: C57BL/6J-Malt1m2Btlr

Allelic Composition: Malt1m2Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m2Btlr

Allelic Composition: Malt1m3Btlr/Malt1m3Btlr
Genetic Background: C57BL/6J-Malt1m3Btlr

Allelic Composition: Malt1m3Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m3Btlr

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Tg(Mef2c-cre)2Blk/0
Genetic Background: Not Specified

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Tg(Mef2c-cre)2Blk/0
Genetic Background: Not Specified

 MP:0008203 absent B-1a cells "absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Chd7Edy/Chd7+
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Ghrm1Btlr/Ghr+
Genetic Background: C57BL/6J-Ghrm1Btlr

Allelic Composition: Malt1m1Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m1Btlr

Allelic Composition: Malt1m2Btlr/Malt1m2Btlr
Genetic Background: C57BL/6J-Malt1m2Btlr

Allelic Composition: Malt1m2Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m2Btlr

Allelic Composition: Malt1m3Btlr/Malt1m3Btlr
Genetic Background: C57BL/6J-Malt1m3Btlr

Allelic Composition: Malt1m3Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000026928 Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*  / reaction / complex
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / reaction / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction / complex
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / reaction / - / complex
 ENSMUSG00000030793 Pycard / Q9EPB4 / PYD and CARD domain containing / PYDC1* / Q9ULZ3* / Q8WXC3* / pyrin domain containing 1*  / reaction / complex
 ENSMUSG00000036526 Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / complex






 

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