ENSMUSG00000030793


Mus musculus

Features
Gene ID: ENSMUSG00000030793
  
Biological name :Pycard
  
Synonyms : Pycard / PYD and CARD domain containing / Q9EPB4
  
Possible biological names infered from orthology : PYDC1 / pyrin domain containing 1 / Q8WXC3 / Q9ULZ3
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 127989708
Gene end: 127993867
  
Corresponding Affymetrix probe sets: 10568355 (MoGene1.0st)   1417346_at (Mouse Genome 430 2.0 Array)   1417347_at (Mouse Genome 430 2.0 Array)   1435973_at (Mouse Genome 430 2.0 Array)   1446926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146211
Ensembl peptide - ENSMUSP00000033056
NCBI entrez gene - 66824     See in Manteia.
MGI - MGI:1931465
RefSeq - NM_023258
RefSeq Peptide - NP_075747
swissprot - A0A0U1RQ20
swissprot - Q54AA2
swissprot - Q9EPB4
Ensembl - ENSMUSG00000030793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pycardENSDARG00000040076Danio rerio
 PYCARDENSG00000103490Homo sapiens
 PYDC1ENSG00000169900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR004020  DAPIN domain
 IPR011029  Death-like domain superfamily
 IPR033516  CARD8/ASC/NALP1, CARD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001773 myeloid dendritic cell activation ISO
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002230 positive regulation of defense response to virus by host IMP
 biological_processGO:0002277 myeloid dendritic cell activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II IMP
 biological_processGO:0002821 positive regulation of adaptive immune response ISO
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032611 interleukin-1 beta production IGI
 biological_processGO:0032688 negative regulation of interferon-beta production ISO
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISO
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0044351 macropinocytosis IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISS
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium ISO
 biological_processGO:0050870 positive regulation of T cell activation ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071347 cellular response to interleukin-1 ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity ISO
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator ISO
 biological_processGO:0090197 positive regulation of chemokine secretion IMP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISO
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IMP
 biological_processGO:2000406 positive regulation of T cell migration IMP
 biological_processGO:2000484 positive regulation of interleukin-8 secretion ISO
 biological_processGO:2000778 positive regulation of interleukin-6 secretion ISO
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity ISO
 biological_processGO:2001181 positive regulation of interleukin-10 secretion ISO
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway ISO
 biological_processGO:2001242 regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008385 IkappaB kinase complex ISO
 cellular_componentGO:0072558 NLRP1 inflammasome complex ISO
 cellular_componentGO:0072559 NLRP3 inflammasome complex ISO
 cellular_componentGO:0097169 AIM2 inflammasome complex ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005138 interleukin-6 receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005523 tropomyosin binding ISO
 molecular_functionGO:0016505 peptidase activator activity involved in apoptotic process ISO
 molecular_functionGO:0017024 myosin I binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0032090 Pyrin domain binding ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046983 protein dimerization activity IMP
 molecular_functionGO:0070700 BMP receptor binding ISO
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
CLEC7A/inflammasome pathway
Neutrophil degranulation
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp1aNeut1/Nlrp1aNeut1,Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3tm1Hhf/Nlrp3+,Rag1tm1Mom/Rag1tm1Mom,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Nlrp3tm1Flv

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: B6.129-Pycardtm1Vmd

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atad1tm1.1Vdaw/Atad1tm1.1Vdaw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atad1tm1.1Vdaw/Atad1tm1.1Vdaw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Atad1tm1.1Vdaw/Atad1tm1.1Vdaw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atad1tm1.1Vdaw/Atad1tm1.1Vdaw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: B6.129-Pycardtm1Vmd

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008564 increased interferon-beta secretion "increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: B6.129-Pycardtm1Vmd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Lhx8tm1Awan/Lhx8tm1Awan
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: B6.129-Pycardtm1Vmd

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Nlrp3tm1Flv/Nlrp3tm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: B6.129-Pycardtm1Vmd

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Pycardtm1Tno/Pycardtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pycardtm1Nnz/Pycardtm1Nnz
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Pycardtm1Tno/Pycardtm1Tno
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: B6.129-Pycardtm1Vmd

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008685 decreased interleukin-18 secretion "reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Pycardtm1Tno/Pycardtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pycardtm1Nnz/Pycardtm1Nnz
Genetic Background: involves: 129 * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pycardtm1Tno/Pycardtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pycardtm1Vmd/Pycardtm1Vmd
Genetic Background: B6.129-Pycardtm1Vmd

 MP:0008896 increased IgG2c level "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atad1tm1.1Vdaw/Atad1tm1.1Vdaw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atad1tm1.1Vdaw/Atad1tm1.1Vdaw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000022534 Mefv / Pyrin / Q9JJ26 / O15553* / MEFV, pyrin innate immunity regulator*  / complex / reaction
 ENSMUSG00000037860 Aim2 / Q91VJ1 / Interferon-inducible protein AIM2 / O14862* / absent in melanoma 2*  / complex / reaction
 ENSMUSG00000025888 Casp1 / P29452 / Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10 / P29466* / caspase 1*  / complex / reaction
 ENSMUSG00000030793 Pycard / Q9EPB4 / PYD and CARD domain containing / PYDC1* / Q9ULZ3* / Q8WXC3* / pyrin domain containing 1*  / complex / reaction
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / complex / reaction






 

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