ENSMUSG00000037860


Mus musculus

Features
Gene ID: ENSMUSG00000037860
  
Biological name :Aim2
  
Synonyms : Aim2 / Interferon-inducible protein AIM2 / Q91VJ1
  
Possible biological names infered from orthology : absent in melanoma 2 / O14862
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 173350879
Gene end: 173466040
  
Corresponding Affymetrix probe sets: 10351867 (MoGene1.0st)   1426619_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119465
Ensembl peptide - ENSMUSP00000121333
Ensembl peptide - ENSMUSP00000132253
Ensembl peptide - ENSMUSP00000134329
NCBI entrez gene - 383619     See in Manteia.
MGI - MGI:2686159
RefSeq - XM_017321511
RefSeq - XM_017321501
RefSeq - XM_017321505
RefSeq - XM_017321507
RefSeq - XM_017321510
RefSeq - NM_001013779
RefSeq - XM_006496919
RefSeq - XM_006496926
RefSeq - XM_006496929
RefSeq - XM_011238831
RefSeq - XM_011238835
RefSeq - XM_011238842
RefSeq - XM_017321480
RefSeq - XM_017321482
RefSeq - XM_017321483
RefSeq - XM_017321486
RefSeq - XM_017321487
RefSeq - XM_017321488
RefSeq - XM_017321492
RefSeq - XM_017321494
RefSeq - XM_017321496
RefSeq - XM_017321498
RefSeq Peptide - NP_001013801
swissprot - G3UZ36
swissprot - D3Z341
swissprot - Q91VJ1
Ensembl - ENSMUSG00000037860
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AIM2ENSG00000163568Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ifi209 / Q8BV49 / Pyrin and HIN domain-containing protein 1 ENSMUSG0000004326330
Ifi206ENSMUSG0000003784929
Ifi207ENSMUSG0000007349029
Ifi203ENSMUSG0000003999729
Mnda / P0DOV1 / Interferon-activable protein 205-B / IFI16* / PYHIN1* / Q16666* / Q6K0P9* / pyrin and HIN domain family member 1* / interferon gamma inducible protein 16*ENSMUSG0000002653627
Ifi205 / Q8CGE8 / Interferon-activable protein 205-A / IFI16* / Q6K0P9* / PYHIN1* / Q16666* / pyrin and HIN domain family member 1* / interferon gamma inducible protein 16*ENSMUSG0000005420327
Mndal / D0QMC3 / Myeloid cell nuclear differentiation antigen-like protein / IFI16* / PYHIN1* / Q16666* / Q6K0P9* / pyrin and HIN domain family member 1* / interferon gamma inducible protein 16*ENSMUSG0000009027227
Ifi204 / P0DOV2 / Interferon-activable protein 204 / IFI16* / PYHIN1* / Q16666* / Q6K0P9* / pyrin and HIN domain family member 1* / interferon gamma inducible protein 16*ENSMUSG0000007348926
Q9R002 / Ifi202b / Interferon-activable protein 202 ENSMUSG0000002653523
Ifi214ENSMUSG0000007050113
Pydc3 / Q3V3Q4 / Pyrin domain-containing protein 3 ENSMUSG000000666779
Ifi213ENSMUSG000000734914


Protein motifs (from Interpro)
Interpro ID Name
 IPR004020  DAPIN domain
 IPR004021  HIN-200/IF120x
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002230 positive regulation of defense response to virus by host IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032461 positive regulation of protein oligomerization ISO
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0035458 cellular response to interferon-beta IDA
 biological_processGO:0035690 cellular response to drug ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050702 interleukin-1 beta secretion ISO
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0070269 pyroptosis IDA
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0097169 AIM2 inflammasome complex ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
The AIM2 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Slc39a14tm1Lex/Slc39a14tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic Background: C57BL/6-Aim2tm1.1Vmd

Allelic Composition: Aim2tm1Ktak/Aim2tm1Ktak
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic Background: C57BL/6-Aim2tm1.1Vmd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic Background: C57BL/6-Aim2tm1.1Vmd

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic Background: C57BL/6-Aim2tm1.1Vmd

 MP:0008564 increased interferon-beta secretion "increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic Background: C57BL/6-Aim2tm1.1Vmd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Aim2tm1Ktak/Aim2tm1Ktak
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Aim2tm1Ktak/Aim2tm1Ktak
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic Background: C57BL/6-Aim2tm1.1Vmd

Allelic Composition: Aim2tm1Ktak/Aim2tm1Ktak
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aim2Gt(CSG445)Byg/Aim2Gt(CSG445)Byg
Genetic Background: B6.129P2-Aim2Gt(CSG445)Byg/J

 MP:0008685 decreased interleukin-18 secretion "reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Aim2tm1.1Vmd/Aim2tm1.1Vmd
Genetic Background: C57BL/6-Aim2tm1.1Vmd

Allelic Composition: Aim2tm1Ktak/Aim2tm1Ktak
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aim2tm1Ktak/Aim2tm1Ktak
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aim2Gt(CSG445)Byg/Aim2Gt(CSG445)Byg
Genetic Background: B6.129P2-Aim2Gt(CSG445)Byg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030793 Pycard / Q9EPB4 / PYD and CARD domain containing / PYDC1* / Q9ULZ3* / Q8WXC3* / pyrin domain containing 1*  / complex / reaction
 ENSMUSG00000025888 Casp1 / P29452 / Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10 / P29466* / caspase 1*  / complex / reaction
 ENSMUSG00000037860 Aim2 / Q91VJ1 / Interferon-inducible protein AIM2 / O14862* / absent in melanoma 2*  / complex






 

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