ENSMUSG00000073489


Mus musculus

Features
Gene ID: ENSMUSG00000073489
  
Biological name :Ifi204
  
Synonyms : Ifi204 / Interferon-activable protein 204 / P0DOV2
  
Possible biological names infered from orthology : IFI16 / interferon gamma inducible protein 16 / PYHIN1 / pyrin and HIN domain family member 1 / Q16666 / Q6K0P9
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 173747293
Gene end: 173766943
  
Corresponding Affymetrix probe sets: 1419603_at (Mouse Genome 430 2.0 Array)   1452348_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106845
NCBI entrez gene - 15951     See in Manteia.
MGI - MGI:96429
RefSeq - XM_006496675
RefSeq - NM_008329
RefSeq Peptide - NP_032355
swissprot - P0DOV2
swissprot - E9QKL6
Ensembl - ENSMUSG00000073489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IFI16ENSG00000163565Homo sapiens
 PYHIN1ENSG00000163564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mnda / P0DOV1 / Interferon-activable protein 205-B / IFI16* / PYHIN1* / Q16666* / Q6K0P9* / pyrin and HIN domain family member 1* / interferon gamma inducible protein 16*ENSMUSG0000002653658
Ifi205 / Q8CGE8 / Interferon-activable protein 205-A / IFI16* / Q6K0P9* / PYHIN1* / Q16666* / pyrin and HIN domain family member 1* / interferon gamma inducible protein 16*ENSMUSG0000005420351
Mndal / D0QMC3 / Myeloid cell nuclear differentiation antigen-like protein / IFI16* / PYHIN1* / Q16666* / Q6K0P9* / pyrin and HIN domain family member 1* / interferon gamma inducible protein 16*ENSMUSG0000009027239
Ifi207ENSMUSG0000007349033
Ifi209 / Q8BV49 / Pyrin and HIN domain-containing protein 1 ENSMUSG0000004326321
Ifi206ENSMUSG0000003784921
Ifi203ENSMUSG0000003999721
Aim2 / Q91VJ1 / Interferon-inducible protein AIM2 / O14862* / absent in melanoma 2*ENSMUSG0000003786015
Q9R002 / Ifi202b / Interferon-activable protein 202 ENSMUSG0000002653514
Pydc3 / Q3V3Q4 / Pyrin domain-containing protein 3 ENSMUSG0000006667712
Ifi214ENSMUSG0000007050111
Ifi213ENSMUSG000000734918


Protein motifs (from Interpro)
Interpro ID Name
 IPR004020  DAPIN domain
 IPR004021  HIN-200/IF120x


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0035457 cellular response to interferon-alpha IDA
 biological_processGO:0035458 cellular response to interferon-beta IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
 biological_processGO:0045669 positive regulation of osteoblast differentiation IGI
 biological_processGO:0048839 inner ear development IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0042405 nuclear inclusion body IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001047 core promoter binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003690 double-stranded DNA binding ISO
 molecular_functionGO:0003712 transcription coregulator activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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