ENSG00000163565


Homo sapiens

Features
Gene ID: ENSG00000163565
  
Biological name :IFI16
  
Synonyms : IFI16 / interferon gamma inducible protein 16 / Q16666
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.1
Gene start: 158999968
Gene end: 159055155
  
Corresponding Affymetrix probe sets: 206332_s_at (Human Genome U133 Plus 2.0 Array)   208965_s_at (Human Genome U133 Plus 2.0 Array)   208966_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456129
Ensembl peptide - ENSP00000456094
Ensembl peptide - ENSP00000458084
Ensembl peptide - ENSP00000295809
Ensembl peptide - ENSP00000342741
Ensembl peptide - ENSP00000352740
Ensembl peptide - ENSP00000357113
Ensembl peptide - ENSP00000357114
Ensembl peptide - ENSP00000404325
Ensembl peptide - ENSP00000406406
Ensembl peptide - ENSP00000407052
NCBI entrez gene - 3428     See in Manteia.
OMIM - 147586
RefSeq - XM_017001150
RefSeq - NM_001206567
RefSeq - NM_005531
RefSeq - XM_005245127
RefSeq - XM_006711290
RefSeq - XM_017001149
RefSeq Peptide - NP_001193496
RefSeq Peptide - NP_005522
swissprot - H3BM18
swissprot - H3BR65
swissprot - H3BR88
swissprot - H3BVE6
swissprot - A0A0A0MRB1
swissprot - X6RHM1
swissprot - Q16666
Ensembl - ENSG00000163565
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ifi204ENSMUSG00000073489Mus musculus
 Ifi205ENSMUSG00000054203Mus musculus
 MndaENSMUSG00000026536Mus musculus
 MndalENSMUSG00000090272Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PYHIN1 / Q6K0P9 / pyrin and HIN domain family member 1ENSG0000016356442
MNDA / P41218 / myeloid cell nuclear differentiation antigenENSG0000016356328
AIM2 / O14862 / absent in melanoma 2ENSG0000016356817


Protein motifs (from Interpro)
Interpro ID Name
 IPR004020  DAPIN domain
 IPR004021  HIN-200/IF120x
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001819 positive regulation of cytokine production TAS
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0010506 regulation of autophagy IEP
 biological_processGO:0030097 hemopoiesis NAS
 biological_processGO:0030099 myeloid cell differentiation NAS
 biological_processGO:0030224 monocyte differentiation IDA
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IDA
 biological_processGO:0040029 regulation of gene expression, epigenetic IMP
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045824 negative regulation of innate immune response IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IMP
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses
IRF3-mediated induction of type I IFN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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