ENSG00000163568


Homo sapiens

Features
Gene ID: ENSG00000163568
  
Biological name :AIM2
  
Synonyms : absent in melanoma 2 / AIM2 / O14862
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.2
Gene start: 159062484
Gene end: 159147096
  
Corresponding Affymetrix probe sets: 206513_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357111
Ensembl peptide - ENSP00000357112
NCBI entrez gene - 9447     See in Manteia.
OMIM - 604578
RefSeq - XM_017002848
RefSeq - NM_004833
RefSeq - XM_005245616
RefSeq Peptide - NP_004824
swissprot - Q5T3W0
swissprot - O14862
Ensembl - ENSG00000163568
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Aim2ENSMUSG00000037860Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PYHIN1 / Q6K0P9 / pyrin and HIN domain family member 1ENSG0000016356436
IFI16 / Q16666 / interferon gamma inducible protein 16ENSG0000016356536
MNDA / P41218 / myeloid cell nuclear differentiation antigenENSG0000016356336


Protein motifs (from Interpro)
Interpro ID Name
 IPR004020  DAPIN domain
 IPR004021  HIN-200/IF120x
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032461 positive regulation of protein oligomerization IDA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IDA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050702 interleukin-1 beta secretion IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0070269 pyroptosis IDA
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0097169 AIM2 inflammasome complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
The AIM2 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163568 AIM2 / O14862 / absent in melanoma 2  / -
 ENSG00000103490 PYCARD / Q9ULZ3 / PYD and CARD domain containing  / complex / reaction
 ENSG00000137752 CASP1 / P29466 / caspase 1  / reaction / complex






 

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