ENSG00000137752


Homo sapiens

Features
Gene ID: ENSG00000137752
  
Biological name :CASP1
  
Synonyms : CASP1 / caspase 1 / P29466
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.3
Gene start: 105025443
Gene end: 105035250
  
Corresponding Affymetrix probe sets: 1552703_s_at (Human Genome U133 Plus 2.0 Array)   206011_at (Human Genome U133 Plus 2.0 Array)   209970_x_at (Human Genome U133 Plus 2.0 Array)   211366_x_at (Human Genome U133 Plus 2.0 Array)   211367_s_at (Human Genome U133 Plus 2.0 Array)   211368_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435536
Ensembl peptide - ENSP00000434779
Ensembl peptide - ENSP00000436875
Ensembl peptide - ENSP00000492493
Ensembl peptide - ENSP00000344132
Ensembl peptide - ENSP00000403260
Ensembl peptide - ENSP00000410076
Ensembl peptide - ENSP00000431947
Ensembl peptide - ENSP00000432340
Ensembl peptide - ENSP00000433138
Ensembl peptide - ENSP00000434250
Ensembl peptide - ENSP00000434259
Ensembl peptide - ENSP00000434303
NCBI entrez gene - 834     See in Manteia.
OMIM - 147678
RefSeq - XM_017018396
RefSeq - NM_001223
RefSeq - NM_001257118
RefSeq - NM_001257119
RefSeq - NM_033292
RefSeq - NM_033293
RefSeq - NM_033294
RefSeq - NM_033295
RefSeq - XM_017018393
RefSeq - XM_017018394
RefSeq - XM_017018395
RefSeq Peptide - NP_001214
RefSeq Peptide - NP_001244047
RefSeq Peptide - NP_001244048
RefSeq Peptide - NP_150634
RefSeq Peptide - NP_150635
RefSeq Peptide - NP_150636
RefSeq Peptide - NP_150637
swissprot - P29466
swissprot - Q5FBZ0
swissprot - B4DVD8
swissprot - G3V169
swissprot - H0YEC7
swissprot - A0A1W2PRX7
Ensembl - ENSG00000137752
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 caspaENSDARG00000008165Danio rerio
 caspbENSDARG00000052039Danio rerio
 caspblENSDARG00000094433Danio rerio
 zgc:171731ENSDARG00000014657Danio rerio
 ENSGALG00000001049Gallus gallus
 Casp1ENSMUSG00000025888Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP4 / P49662 / caspase 4ENSG0000019695446
CASP5 / P51878 / caspase 5ENSG0000013775744
CASP12 / Q6UXS9 / caspase 12 (gene/pseudogene)ENSG0000020440336


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016540 protein autoprocessing IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032611 interleukin-1 beta production IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050717 positive regulation of interleukin-1 alpha secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IMP
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0051882 mitochondrial depolarization IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0070269 pyroptosis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 biological_processGO:0071346 cellular response to interferon-gamma IMP
 biological_processGO:0097300 programmed necrotic cell death IEA
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0072557 IPAF inflammasome complex IBA
 cellular_componentGO:0072558 NLRP1 inflammasome complex IDA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IDA
 cellular_componentGO:0097169 AIM2 inflammasome complex IDA
 cellular_componentGO:0097179 protease inhibitor complex IMP
 molecular_functionGO:0004175 endopeptidase activity IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IMP
 molecular_functionGO:0050700 CARD domain binding IPI
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Interleukin-1 processing
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The AIM2 inflammasome
The IPAF inflammasome
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103490 PYCARD / Q9ULZ3 / PYD and CARD domain containing  / complex / reaction
 ENSG00000125571 IL37 / Q9NZH6 / interleukin 37  / complex
 ENSG00000165416 SUGT1 / Q9Y2Z0 / SGT1 homolog, MIS12 kinetochore complex assembly cochaperone  / reaction / complex
 ENSG00000162711 NLRP3 / Q96P20 / NLR family pyrin domain containing 3  / reaction / complex
 ENSG00000091106 NLRC4 / Q9NPP4 / NLR family CARD domain containing 4  / complex / reaction
 ENSG00000142192 APP / P05067 / amyloid beta precursor protein  / reaction / complex
 ENSG00000137752 CASP1 / P29466 / caspase 1  / reaction / complex
 ENSG00000150782 IL18 / Q14116 / interleukin 18  / reaction
 ENSG00000125538 IL1B / P01584 / interleukin 1 beta  / reaction
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex / reaction
 ENSG00000163568 AIM2 / O14862 / absent in melanoma 2  / reaction / complex






 

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