ENSG00000150782


Homo sapiens

Features
Gene ID: ENSG00000150782
  
Biological name :IL18
  
Synonyms : IL18 / interleukin 18 / Q14116
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q23.1
Gene start: 112143251
Gene end: 112164117
  
Corresponding Affymetrix probe sets: 206295_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434561
Ensembl peptide - ENSP00000280357
Ensembl peptide - ENSP00000434161
NCBI entrez gene - 3606     See in Manteia.
OMIM - 600953
RefSeq - XM_011542806
RefSeq - NM_001243211
RefSeq - NM_001562
RefSeq - XM_011542805
RefSeq Peptide - NP_001553
RefSeq Peptide - NP_001230140
swissprot - Q14116
swissprot - A0A024R3E0
Ensembl - ENSG00000150782
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL18ENSGALG00000007874Gallus gallus
 Il18ENSMUSG00000039217Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR008996  Cytokine IL1/FGF
 IPR015529  Interleukin-18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030101 natural killer cell activation IEA
 biological_processGO:0030155 regulation of cell adhesion IDA
 biological_processGO:0030431 sleep ISS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032148 activation of protein kinase B activity IDA
 biological_processGO:0032609 interferon-gamma production IEA
 biological_processGO:0032635 interleukin-6 production IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0032740 positive regulation of interleukin-17 production IDA
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IDA
 biological_processGO:0034105 positive regulation of tissue remodeling IC
 biological_processGO:0035655 interleukin-18-mediated signaling pathway IDA
 biological_processGO:0035744 T-helper 1 cell cytokine production IEA
 biological_processGO:0042033 chemokine biosynthetic process TAS
 biological_processGO:0042088 T-helper 1 type immune response IDA
 biological_processGO:0042092 type 2 immune response TAS
 biological_processGO:0042094 interleukin-2 biosynthetic process TAS
 biological_processGO:0042095 interferon-gamma biosynthetic process TAS
 biological_processGO:0042104 positive regulation of activated T cell proliferation IDA
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0042231 interleukin-13 biosynthetic process TAS
 biological_processGO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process TAS
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation ISS
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050729 positive regulation of inflammatory response IC
 biological_processGO:0051142 positive regulation of NK T cell proliferation IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0070328 triglyceride homeostasis ISS
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005125 cytokine activity ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-1 processing
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137496 IL18BP / O95998 / interleukin 18 binding protein  / complex / reaction
 ENSG00000115607 O95256 / IL18RAP / interleukin 18 receptor accessory protein  / complex / reaction
 ENSG00000115604 IL18R1 / Q13478 / interleukin 18 receptor 1  / reaction / complex
 ENSG00000137752 CASP1 / P29466 / caspase 1  / reaction






 

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