ENSMUSG00000039217


Mus musculus

Features
Gene ID: ENSMUSG00000039217
  
Biological name :Il18
  
Synonyms : Il18 / Interleukin-18 / P70380
  
Possible biological names infered from orthology : Q14116
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.3
Gene start: 50554827
Gene end: 50581840
  
Corresponding Affymetrix probe sets: 10585194 (MoGene1.0st)   1417932_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054591
Ensembl peptide - ENSMUSP00000137193
Ensembl peptide - ENSMUSP00000150305
Ensembl peptide - ENSMUSP00000151002
NCBI entrez gene - 16173     See in Manteia.
MGI - MGI:107936
RefSeq - XM_017313137
RefSeq - NM_008360
RefSeq - XM_006510024
RefSeq - XM_006510026
RefSeq - XM_006510027
RefSeq - XM_006510028
RefSeq Peptide - NP_001344150
RefSeq Peptide - NP_032386
swissprot - Q2PMY2
swissprot - K3W4N2
swissprot - A0A1L1STF5
swissprot - P70380
Ensembl - ENSMUSG00000039217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL18ENSGALG00000007874Gallus gallus
 IL18ENSG00000150782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR008996  Cytokine IL1/FGF
 IPR015529  Interleukin-18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0030101 natural killer cell activation IDA
 biological_processGO:0030155 regulation of cell adhesion ISS
 biological_processGO:0030431 sleep ISS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032635 interleukin-6 production IDA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production ISO
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0032740 positive regulation of interleukin-17 production ISO
 biological_processGO:0032819 positive regulation of natural killer cell proliferation ISO
 biological_processGO:0035655 interleukin-18-mediated signaling pathway ISO
 biological_processGO:0035744 T-helper 1 cell cytokine production IGI
 biological_processGO:0042088 T-helper 1 type immune response ISS
 biological_processGO:0042095 interferon-gamma biosynthetic process IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation ISS
 biological_processGO:0042119 neutrophil activation IDA
 biological_processGO:0042231 interleukin-13 biosynthetic process TAS
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IMP
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0051142 positive regulation of NK T cell proliferation ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005125 cytokine activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 processing
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: C.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
Show

Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: C.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

Allelic Composition: Il18tm1Aki/Il18+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: B6.129P2-Il18tm1Aki

Allelic Composition: Il18tm1Aki/Il18tm1Aki,Il1btm1Dch/Il1btm1Dch
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
Show

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il12btm1Jm/Il12btm1Jm,Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il12btm1Jm/Il12btm1Jm,Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006185 retinal hemorrhage "bleeding into the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(RNAi:Gsk3a,Gsk3b)Rkuhn/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008002 hyperchlorhydria "increased hydrochloric acid content of the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgals1tm1Rob/Lgals1tm1Rob,Myf5tm2Pas/Myf5+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hydinhy3-Tg(Bdnf)459Ove/Hydinhy3-Tg(Bdnf)459Ove
Genetic Background: FVB/N-Hydinhy3-Tg(Bdnf)459Ove

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki,Tg(KRT14-CASP1)1Miz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: B6.129P2-Il18tm1Aki

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hydinhy3-Tg(Bdnf)459Ove/Hydinhy3-Tg(Bdnf)459Ove
Genetic Background: FVB/N-Hydinhy3-Tg(Bdnf)459Ove

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il12btm1Jm/Il12btm1Jm,Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: B6.129P2-Il18tm1Khe

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: B6.129P2-Il18tm1Khe

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: B6.129P2-Il18tm1Khe

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: B6.129P2-Il18tm1Khe

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: B6.129P2-Il18tm1Khe

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: B6.129P2-Il18tm1Aki

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Khe/Il18tm1Khe
Genetic Background: involves: 129P2/OlaHsd

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il18tm1Aki/Il18tm1Aki
Genetic Background: B6.129P2-Il18tm1Aki

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025888 Casp1 / P29452 / Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10 / P29466* / caspase 1*  / reaction
 ENSMUSG00000026068 Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*  / reaction / complex
 ENSMUSG00000070427 Il18bp / Q9Z0M9 / Interleukin-18-binding protein / O95998*  / complex / reaction
 ENSMUSG00000026070 Il18r1 / Q61098 / Interleukin-18 receptor 1 / Q13478*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr