16173


Mus musculus (NCBI)
regulationcellproductionresponseproliferationsignalinginterleukin-processapoptotict-helperpathwaydifferentiationnaturalkilleractivationproteinactivityinterferon-gammafactorbiosyntheticcytokineimmunemacrophagesmoothmusclekinasebneutrophiltphosphorylation

Features
Gene ID: 16173
  
Biological name :
  
Synonyms : Igif|Il-18 / Il18 / interleukin 18
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1417932_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - XP_017168626.1
RefSeq - 1269208322
RefSeq - 1269208431
RefSeq - 568958875
RefSeq - 568958879
RefSeq - 568958881
RefSeq - 568958883
RefSeq - 6680413
RefSeq - NC_000075.6
RefSeq - NP_001344150.1
RefSeq - NP_001344151.1
RefSeq - NP_032386.1
RefSeq - XP_006510087.1
RefSeq - XP_006510089.1
RefSeq - XP_006510090.1
RefSeq - XP_006510091.1
RefSeq - 1039792113
RefSeq - NM_001357221.1
RefSeq - NM_001357222.1
RefSeq - NM_008360.2
RefSeq - XM_006510027.3
RefSeq - XM_006510028.3
RefSeq - XM_017313137.1
RefSeq - XM_006510024.1
RefSeq - XM_006510026.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000039217 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusanatomical structure developmentresponse to stressresponse to abiotic stimulusimmune responsecell deathcellular developmental processlocalization of cellmovement of cell or subcellular componentcell activationcell adhesionsleepresponse to external stimulusresponse to chemicalresponse to biotic stimulusregulation of molecular functioncytokine productionleukocyte proliferationbiosynthetic processcollagen metabolic processregulation of biological qualityproduction of molecular mediator of immune responseimmune effector processleukocyte mediated cytotoxicitysystem processmuscle cell proliferationdetection of stimulusresponse to endogenous stimulusmulticellular organism reproductiontissue remodelingnitrnitrogen compound metabolic processcellcell communicationcellcellular metabolic processprimprimary metabolic processorgaorganic substance metabolic processcellcellular response to stimulusanatanatomical structure developmentrespresponse to stressrespresponse to abiotic stimulusimmuimmune responsecellcell deathcellcellular developmental processlocalocalization of cellmovemovement of cell or subcellular componentcellcell activationcellcell adhesionsleesleeprespresponse to external stimulusrespresponse to chemicalrespresponse to biotic stimulusreguregulation of molecular functioncytocytokine productionleukleukocyte proliferationbiosbiosynthetic processcollcollagen metabolic processreguregulation of biological qualityprodproduction of molecular mediator of immune responseimmuimmune effector processleukleukocyte mediated cytotoxicitysystsystem processmuscmuscle cell proliferationdetedetection of stimulusrespresponse to endogenous stimulusmultmulticellular organism reproductiontisstissue remodeling
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regionextracellular regioncellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0001666 response to hypoxia ISO
 biological_processGO:0006954 inflammatory response ISO
 biological_processGO:0006955 immune response TAS
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0014911 positive regulation of smooth muscle cell migration ISO
 biological_processGO:0030101 natural killer cell activation IDA
 biological_processGO:0030155 regulation of cell adhesion ISS
 biological_processGO:0030431 sleep ISS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032635 interleukin-6 production IDA
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production ISO
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0032740 positive regulation of interleukin-17 production ISO
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISO
 biological_processGO:0032819 positive regulation of natural killer cell proliferation ISO
 biological_processGO:0032930 positive regulation of superoxide anion generation ISO
 biological_processGO:0032967 positive regulation of collagen biosynthetic process ISO
 biological_processGO:0033030 negative regulation of neutrophil apoptotic process ISO
 biological_processGO:0035655 interleukin-18-mediated signaling pathway ISO
 biological_processGO:0035744 T-helper 1 cell cytokine production IGI
 biological_processGO:0042088 T-helper 1 type immune response ISS
 biological_processGO:0042095 interferon-gamma biosynthetic process IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation ISS
 biological_processGO:0042119 neutrophil activation IDA
 biological_processGO:0042231 interleukin-13 biosynthetic process TAS
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043117 positive regulation of vascular permeability ISO
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISO
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IMP
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051142 positive regulation of NK T cell proliferation ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:0071375 cellular response to peptide hormone stimulus ISO
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 biological_processGO:2000256 positive regulation of male germ cell proliferation ISO
 biological_processGO:2000504 positive regulation of blood vessel remodeling ISO
 biological_processGO:2000556 positive regulation of T-helper 1 cell cytokine production ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0016324 apical plasma membrane ISO
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0045515 interleukin-18 receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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