ENSMUSG00000025888


Mus musculus

Features
Gene ID: ENSMUSG00000025888
  
Biological name :Casp1
  
Synonyms : Casp1 / Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10 / P29452
  
Possible biological names infered from orthology : caspase 1 / P29466
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 5298517
Gene end: 5307265
  
Corresponding Affymetrix probe sets: 10582985 (MoGene1.0st)   1449265_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027015
NCBI entrez gene - 12362     See in Manteia.
MGI - MGI:96544
RefSeq - NM_009807
RefSeq Peptide - NP_033937
swissprot - P29452
Ensembl - ENSMUSG00000025888
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 caspaENSDARG00000008165Danio rerio
 caspbENSDARG00000052039Danio rerio
 caspblENSDARG00000094433Danio rerio
 zgc:171731ENSDARG00000014657Danio rerio
 ENSGALG00000001049Gallus gallus
 CASP1ENSG00000137752Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casp4 / P70343 / Caspase-4 Caspase-4 subunit p10 Caspase-4 subunit p20 / CASP5* / P49662* / P51878* / caspase 5* / caspase 4*ENSMUSG0000003353840
Casp12 / O08736 / Caspase-12 / Q6UXS9* / caspase 12 (gene/pseudogene)*ENSMUSG0000002588740


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0016485 protein processing IMP
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032611 interleukin-1 beta production IGI
 biological_processGO:0033198 response to ATP IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IMP
 biological_processGO:0050717 positive regulation of interleukin-1 alpha secretion IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0051882 mitochondrial depolarization IMP
 biological_processGO:0060081 membrane hyperpolarization IMP
 biological_processGO:0070269 pyroptosis IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0097300 programmed necrotic cell death IDA
 biological_processGO:1901998 toxin transport IMP
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0072557 IPAF inflammasome complex IDA
 cellular_componentGO:0072558 NLRP1 inflammasome complex IEA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IEA
 cellular_componentGO:0097169 AIM2 inflammasome complex IEA
 cellular_componentGO:0097179 protease inhibitor complex IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0050700 CARD domain binding IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Interleukin-1 processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Flv

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1r/Slc11a1r
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1r/Slc11a1s
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * NOD

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Rb1tm2Mlh/Rb1+
Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

 MP:0008639 decreased circulating interleukin-1 alpha level "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

 MP:0008685 decreased interleukin-18 secretion "reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s
Genetic Background: B6.129S2-Casp1tm1Flv

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1r/Slc11a1r
Genetic Background: involves: 129S2/SvPas

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr
Genetic Background: C57BL/6J-Adam17m1Btlr

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039217 Il18 / P70380 / Interleukin-18 / Q14116*  / reaction
 ENSMUSG00000025888 Casp1 / P29452 / Caspase-1 Caspase-1 subunit p20 Caspase-1 subunit p10 / P29466* / caspase 1*  / reaction / complex
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / reaction
 ENSMUSG00000030793 Pycard / Q9EPB4 / PYD and CARD domain containing / PYDC1* / Q9ULZ3* / Q8WXC3* / pyrin domain containing 1*  / reaction / complex
 ENSMUSG00000037860 Aim2 / Q91VJ1 / Interferon-inducible protein AIM2 / O14862* / absent in melanoma 2*  / reaction / complex






 

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