MP:0001273 | decreased metastatic potential | |
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr Genetic Background: C57BL/6J-Adam17m1Btlr
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MP:0001648 | abnormal apoptosis | "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0001845 | abnormal inflammatory response | "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0001876 | decreased inflammatory response | "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hexatm1Cota/Hexatm1Cota Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0002411 | decreased susceptibility to bacterial infection | "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hexatm1Cota/Hexatm1Cota Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s Genetic Background: B6.129S2-Casp1tm1Flv
Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1r/Slc11a1r Genetic Background: involves: 129S2/SvPas
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1s/Slc11a1s Genetic Background: B6.129S2-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1r/Slc11a1s Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del
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MP:0002451 | abnormal macrophage physiology | "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+ Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * NOD
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Slc11a1s/Slc11a1s Genetic Background: B6.129S2-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del
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MP:0002463 | abnormal neutrophil physiology | "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0003091 | abnormal cell migration | "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0003204 | decreased neuron apoptosis | "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr Genetic Background: C57BL/6J-Adam17m1Btlr
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MP:0003606 | kidney failure | "cessation of renal function" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del Genetic Background: B6.129S2-Casp1tm1Flv
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MP:0004154 | renal tubular necrosis | "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del Genetic Background: B6.129S2-Casp1tm1Flv
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MP:0004502 | decreased incidence of chemically-induced tumors | "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Osr1-cre)4Mrt/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0004800 | decreased susceptibility to experimental autoimmune encephalomyelitis | "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hexatm1Cota/Hexatm1Cota Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0005528 | decreased glomerular filtration rate | "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: KitW-sh/KitW-v Genetic Background: involves: 101/H * C3H/HeH
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MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J
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MP:0006043 | decreased apoptosis | "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hexatm1Cota/Hexatm1Cota Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
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MP:0006059 | decreased susceptibility to ischemic brain injury | "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0006414 | decreased T cell apoptosis | "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0008537 | increased susceptibility to induced colitis | "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del Genetic Background: B6.129S2-Casp1tm1Flv
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MP:0008554 | decreased circulating tumor necrosis factor level | "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0008561 | decreased tumor necrosis factor secretion | "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008567 | decreased interferon-gamma secretion | "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008578 | decreased circulating interferon-gamma level | "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008597 | decreased circulating interleukin-6 level | "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Rb1tm2Mlh/Rb1+ Genetic Background: either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
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MP:0008636 | decreased circulating interleukin-18 level | "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518] |
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Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ
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MP:0008639 | decreased circulating interleukin-1 alpha level | "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300] |
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Allelic Composition: Dhhtm1Amc/Dhhtm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Casp4tm1.1Gne/Casp4tm1.1Gne Genetic Background: involves: C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
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MP:0008642 | decreased circulating interleukin-1 beta level | "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Dhhtm1Amc/Dhhtm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * Swiss Webster
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Casp4tm1.1Gne/Casp4tm1.1Gne Genetic Background: involves: C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ
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MP:0008655 | decreased interleukin-1 alpha secretion | "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ
Allelic Composition: Casp4tm1.1Gne/Casp4tm1.1Gne Genetic Background: involves: C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ
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MP:0008658 | decreased interleukin-1 beta secretion | "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ
Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del Genetic Background: B6.129S2-Casp1tm1Flv
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del
Allelic Composition: Casp4tm1.1Gne/Casp4tm1.1Gne Genetic Background: involves: C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ
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MP:0008685 | decreased interleukin-18 secretion | "reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ
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MP:0008706 | decreased interleukin-6 secretion | "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008720 | impaired neutrophil migration | "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008734 | decreased susceptibility to endotoxin shock | "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Il1r1tm1Imx/Il1r1tm1Imx Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Casp4tm1.1Gne/Casp4tm1.1Gne Genetic Background: involves: C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ
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MP:0009481 | cecum inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s Genetic Background: B6.129S2-Casp1tm1Flv
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MP:0009542 | decreased thymocyte apoptosis | "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1s/Slc11a1s Genetic Background: B6.129S2-Casp1tm1Flv
Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Slc11a1r/Slc11a1r Genetic Background: involves: 129S2/SvPas
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MP:0009764 | decreased sensitivity to induced morbidity/mortality | "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17m1Btlr/Adam17m1Btlr Genetic Background: C57BL/6J-Adam17m1Btlr
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MP:0009767 | decreased sensitivity to xenobiotic induced morbidity/mortality | "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp4tm1.1Gne/Casp4tm1.1Gne Genetic Background: involves: C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
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MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: C3.129S2-Casp1tm1Sesh Casp4del
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MP:0009789 | decreased susceptibility to bacterial infection induced morbidity/mortality | "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hexatm1Cota/Hexatm1Cota Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010377 | abnormal gut flora balance | "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del Genetic Background: B6.129S2-Casp1tm1Flv
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MP:0011081 | decreased macrophage apoptosis | "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Casp4tm1.1Gne/Casp4tm1.1Gne Genetic Background: involves: C57BL/6
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del Genetic Background: B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del,Tg(Casp4)#Gne/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ
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