ENSG00000137757


Homo sapiens

Features
Gene ID: ENSG00000137757
  
Biological name :CASP5
  
Synonyms : CASP5 / caspase 5 / P51878
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.3
Gene start: 104994235
Gene end: 105023168
  
Corresponding Affymetrix probe sets: 207500_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000415241
Ensembl peptide - ENSP00000434471
Ensembl peptide - ENSP00000436877
Ensembl peptide - ENSP00000260315
Ensembl peptide - ENSP00000376849
Ensembl peptide - ENSP00000388365
Ensembl peptide - ENSP00000396053
Ensembl peptide - ENSP00000398130
Ensembl peptide - ENSP00000408455
NCBI entrez gene - 838     See in Manteia.
OMIM - 602665
RefSeq - NM_004347
RefSeq - XM_011543021
RefSeq - NM_001136109
RefSeq - NM_001136110
RefSeq - NM_001136112
RefSeq Peptide - NP_001129581
RefSeq Peptide - NP_001129582
RefSeq Peptide - NP_001129584
RefSeq Peptide - NP_004338
swissprot - C9JF14
swissprot - H7C0P5
swissprot - P51878
Ensembl - ENSG00000137757
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 caspaENSDARG00000008165Danio rerio
 caspbENSDARG00000052039Danio rerio
 caspblENSDARG00000094433Danio rerio
 zgc:171731ENSDARG00000014657Danio rerio
 ENSGALG00000001049Gallus gallus
 Casp4ENSMUSG00000033538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP4 / P49662 / caspase 4ENSG0000019695460
CASP1 / P29466 / caspase 1ENSG0000013775239
CASP12 / Q6UXS9 / caspase 12 (gene/pseudogene)ENSG0000020440336


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 cellular_componentGO:0072558 NLRP1 inflammasome complex IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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