ENSG00000196954


Homo sapiens

Features
Gene ID: ENSG00000196954
  
Biological name :CASP4
  
Synonyms : CASP4 / caspase 4 / P49662
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.3
Gene start: 104942866
Gene end: 104969436
  
Corresponding Affymetrix probe sets: 209310_s_at (Human Genome U133 Plus 2.0 Array)   213596_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432879
Ensembl peptide - ENSP00000376857
Ensembl peptide - ENSP00000388566
Ensembl peptide - ENSP00000401673
NCBI entrez gene - 837     See in Manteia.
OMIM - 602664
RefSeq - XM_017018397
RefSeq - NM_001225
RefSeq - NM_033306
RefSeq - XM_011543019
RefSeq Peptide - NP_001216
RefSeq Peptide - NP_150649
swissprot - H0YD34
swissprot - P49662
swissprot - E9PMT1
Ensembl - ENSG00000196954
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 caspaENSDARG00000008165Danio rerio
 caspbENSDARG00000052039Danio rerio
 caspblENSDARG00000094433Danio rerio
 zgc:171731ENSDARG00000014657Danio rerio
 ENSGALG00000001049Gallus gallus
 Casp4ENSMUSG00000033538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP5 / P51878 / caspase 5ENSG0000013775771
CASP1 / P29466 / caspase 1ENSG0000013775249
CASP12 / Q6UXS9 / caspase 12 (gene/pseudogene)ENSG0000020440345


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:1904646 cellular response to amyloid-beta IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0061702 inflammasome complex IEA
 cellular_componentGO:0072557 IPAF inflammasome complex IBA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IBA
 cellular_componentGO:0097169 AIM2 inflammasome complex IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0050700 CARD domain binding IPI
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr