ENSG00000115604


Homo sapiens

Features
Gene ID: ENSG00000115604
  
Biological name :IL18R1
  
Synonyms : IL18R1 / interleukin 18 receptor 1 / Q13478
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q12.1
Gene start: 102311529
Gene end: 102398775
  
Corresponding Affymetrix probe sets: 206618_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000233957
Ensembl peptide - ENSP00000334030
Ensembl peptide - ENSP00000386663
Ensembl peptide - ENSP00000387211
NCBI entrez gene - 8809     See in Manteia.
OMIM - 604494
RefSeq - XM_017005184
RefSeq - NM_001282399
RefSeq - NM_003855
RefSeq - XM_011512099
RefSeq - XM_017005181
RefSeq - XM_017005182
RefSeq - XM_017005183
RefSeq - XM_005264039
RefSeq - XM_005264040
RefSeq Peptide - NP_003846
RefSeq Peptide - NP_001269328
swissprot - Q13478
swissprot - Q86YL8
Ensembl - ENSG00000115604
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL18R1ENSGALG00000040621Gallus gallus
 Il18r1ENSMUSG00000026070Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NP60 / IL1RAPL2 / interleukin 1 receptor accessory protein like 2ENSG0000018910828
Q9NZN1 / IL1RAPL1 / interleukin 1 receptor accessory protein like 1ENSG0000016930627
IL1RL1 / Q01638 / interleukin 1 receptor like 1ENSG0000011560226
IL1R1 / P14778 / interleukin 1 receptor type 1ENSG0000011559425
IL1RAP / Q9NPH3 / interleukin 1 receptor accessory proteinENSG0000019608325
O95256 / IL18RAP / interleukin 18 receptor accessory proteinENSG0000011560724
IL1RL2 / Q9HB29 / interleukin 1 receptor like 2ENSG0000011559822
IL1R2 / P27930 / interleukin 1 receptor type 2ENSG0000011559011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0030101 natural killer cell activation IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0035655 interleukin-18-mediated signaling pathway TAS
 biological_processGO:0045063 T-helper 1 cell differentiation IEA
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042008 interleukin-18 receptor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-37 signaling
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000185187 Q6IA17 / SIGIRR / single Ig and TIR domain containing  / reaction / complex
 ENSG00000125571 IL37 / Q9NZH6 / interleukin 37  / complex / reaction
 ENSG00000115607 O95256 / IL18RAP / interleukin 18 receptor accessory protein  / reaction / complex
 ENSG00000150782 IL18 / Q14116 / interleukin 18  / complex / reaction






 

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