ENSG00000115602


Homo sapiens

Features
Gene ID: ENSG00000115602
  
Biological name :IL1RL1
  
Synonyms : IL1RL1 / interleukin 1 receptor like 1 / Q01638
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q12.1
Gene start: 102311502
Gene end: 102352037
  
Corresponding Affymetrix probe sets: 207526_s_at (Human Genome U133 Plus 2.0 Array)   210442_at (Human Genome U133 Plus 2.0 Array)   234066_at (Human Genome U133 Plus 2.0 Array)   242809_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391120
Ensembl peptide - ENSP00000384822
Ensembl peptide - ENSP00000409437
Ensembl peptide - ENSP00000386618
Ensembl peptide - ENSP00000233954
Ensembl peptide - ENSP00000310371
NCBI entrez gene - 9173     See in Manteia.
OMIM - 601203
RefSeq - XM_006712839
RefSeq - XM_011512151
RefSeq - NM_001282408
RefSeq - NM_003856
RefSeq - NM_016232
RefSeq Peptide - NP_001269337
RefSeq Peptide - NP_003847
RefSeq Peptide - NP_057316
swissprot - Q01638
swissprot - E9PC41
swissprot - C9JSY6
Ensembl - ENSG00000115602
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01054965.1ENSDARG00000090844Danio rerio
 CU855885.1ENSDARG00000101527Danio rerio
 IL1RL1ENSGALG00000016785Gallus gallus
 Il1rl1ENSMUSG00000026069Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL1R1 / P14778 / interleukin 1 receptor type 1ENSG0000011559428
IL1RL2 / Q9HB29 / interleukin 1 receptor like 2ENSG0000011559826
Q9NP60 / IL1RAPL2 / interleukin 1 receptor accessory protein like 2ENSG0000018910825
IL18R1 / Q13478 / interleukin 18 receptor 1ENSG0000011560425
IL1RAP / Q9NPH3 / interleukin 1 receptor accessory proteinENSG0000019608324
Q9NZN1 / IL1RAPL1 / interleukin 1 receptor accessory protein like 1ENSG0000016930624
O95256 / IL18RAP / interleukin 18 receptor accessory proteinENSG0000011560722
IL1R2 / P27930 / interleukin 1 receptor type 2ENSG0000011559013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002826 negative regulation of T-helper 1 type immune response IEA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032754 positive regulation of interleukin-5 production IEA
 biological_processGO:0038172 interleukin-33-mediated signaling pathway TAS
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0090197 positive regulation of chemokine secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002113 interleukin-33 binding IEA
 molecular_functionGO:0002114 interleukin-33 receptor activity IEA
 molecular_functionGO:0004896 cytokine receptor activity TAS
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex
 ENSG00000137033 IL33 / O95760 / interleukin 33  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex






 

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