ENSG00000115594


Homo sapiens

Features
Gene ID: ENSG00000115594
  
Biological name :IL1R1
  
Synonyms : IL1R1 / interleukin 1 receptor type 1 / P14778
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q11.2
Gene start: 102064544
Gene end: 102179874
  
Corresponding Affymetrix probe sets: 202948_at (Human Genome U133 Plus 2.0 Array)   215561_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387131
Ensembl peptide - ENSP00000386776
Ensembl peptide - ENSP00000390349
Ensembl peptide - ENSP00000415366
Ensembl peptide - ENSP00000411627
Ensembl peptide - ENSP00000410461
Ensembl peptide - ENSP00000408101
Ensembl peptide - ENSP00000407017
Ensembl peptide - ENSP00000401646
Ensembl peptide - ENSP00000393296
Ensembl peptide - ENSP00000386380
Ensembl peptide - ENSP00000386478
Ensembl peptide - ENSP00000386555
NCBI entrez gene - 3554     See in Manteia.
OMIM - 147810
RefSeq - XM_017003989
RefSeq - NM_000877
RefSeq - NM_001288706
RefSeq - NM_001320978
RefSeq - NM_001320980
RefSeq - NM_001320981
RefSeq - NM_001320982
RefSeq - NM_001320983
RefSeq - NM_001320984
RefSeq - NM_001320985
RefSeq - NM_001320986
RefSeq - XM_005263930
RefSeq - XM_005263934
RefSeq - XM_011511115
RefSeq - XM_011511116
RefSeq - XM_011511117
RefSeq - XM_011511118
RefSeq Peptide - NP_001307915
RefSeq Peptide - NP_000868
RefSeq Peptide - NP_001275635
RefSeq Peptide - NP_001307907
RefSeq Peptide - NP_001307909
RefSeq Peptide - NP_001307910
RefSeq Peptide - NP_001307911
RefSeq Peptide - NP_001307912
RefSeq Peptide - NP_001307913
RefSeq Peptide - NP_001307914
swissprot - B9A040
swissprot - B8ZZW4
swissprot - P14778
swissprot - B8ZZ73
swissprot - F8WF92
swissprot - H7BZM5
swissprot - C9JWB2
swissprot - C9JW84
swissprot - C9JQ36
swissprot - C9J686
swissprot - C9J3W8
Ensembl - ENSG00000115594
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01054965.1ENSDARG00000090844Danio rerio
 CU855885.1ENSDARG00000101527Danio rerio
 ENSGALG00000030526Gallus gallus
 IL1R1ENSGALG00000043044Gallus gallus
 Il1r1ENSMUSG00000026072Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL1RL2 / Q9HB29 / interleukin 1 receptor like 2ENSG0000011559840
Q9NP60 / IL1RAPL2 / interleukin 1 receptor accessory protein like 2ENSG0000018910827
IL1RL1 / Q01638 / interleukin 1 receptor like 1ENSG0000011560227
Q9NZN1 / IL1RAPL1 / interleukin 1 receptor accessory protein like 1ENSG0000016930626
IL18R1 / Q13478 / interleukin 18 receptor 1ENSG0000011560424
O95256 / IL18RAP / interleukin 18 receptor accessory proteinENSG0000011560722
IL1RAP / Q9NPH3 / interleukin 1 receptor accessory proteinENSG0000019608321
IL1R2 / P27930 / interleukin 1 receptor type 2ENSG0000011559018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR004076  Interleukin-1 receptor type 1
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IDA
 biological_processGO:2000391 positive regulation of neutrophil extravasation IEA
 biological_processGO:2000661 positive regulation of interleukin-1-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0004909 interleukin-1, type I, activating receptor activity IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019966 interleukin-1 binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125538 IL1B / P01584 / interleukin 1 beta  / complex / reaction
 ENSG00000136689 IL1RN / P18510 / interleukin 1 receptor antagonist  / reaction / complex
 ENSG00000115008 IL1A / P01583 / interleukin 1 alpha  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000078902 Q9H0E2 / TOLLIP / toll interacting protein  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction






 

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