ENSG00000078902


Homo sapiens

Features
Gene ID: ENSG00000078902
  
Biological name :TOLLIP
  
Synonyms : Q9H0E2 / toll interacting protein / TOLLIP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 1274371
Gene end: 1309654
  
Corresponding Affymetrix probe sets: 217930_s_at (Human Genome U133 Plus 2.0 Array)   222469_s_at (Human Genome U133 Plus 2.0 Array)   233881_s_at (Human Genome U133 Plus 2.0 Array)   237342_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432668
Ensembl peptide - ENSP00000314733
Ensembl peptide - ENSP00000432778
Ensembl peptide - ENSP00000436393
Ensembl peptide - ENSP00000434494
Ensembl peptide - ENSP00000434035
Ensembl peptide - ENSP00000263646
NCBI entrez gene - 54472     See in Manteia.
OMIM - 606277
RefSeq - XM_017017931
RefSeq - NM_001318512
RefSeq - NM_001318514
RefSeq - NM_001318515
RefSeq - NM_001318516
RefSeq - NM_019009
RefSeq Peptide - NP_001305445
RefSeq Peptide - NP_001305441
RefSeq Peptide - NP_001305443
RefSeq Peptide - NP_001305444
RefSeq Peptide - NP_061882
swissprot - E9PNS3
swissprot - F2Z2Y8
swissprot - E9PQ25
swissprot - Q6FIE9
swissprot - Q9H0E2
swissprot - E7EN89
swissprot - E9PP67
Ensembl - ENSG00000078902
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tollipENSDARG00000098486Danio rerio
 TOLLIPENSGALG00000006697Gallus gallus
 Q9QZ06ENSMUSG00000025139Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR003892  Ubiquitin system component Cue
 IPR009060  UBA-like superfamily
 IPR035892  C2 domain superfamily
 IPR037301  Toll-interacting protein, C2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0030855 epithelial cell differentiation IEP
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0035556 intracellular signal transduction NAS
 biological_processGO:0036010 protein localization to endosome IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045321 leukocyte activation NAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0045092 interleukin-18 receptor complex NAS
 cellular_componentGO:0045323 interleukin-1 receptor complex NAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity NAS
 molecular_functionGO:0005150 interleukin-1, type I receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0035325 Toll-like receptor binding IPI
 molecular_functionGO:0043130 ubiquitin binding IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / complex / reaction
 ENSG00000125538 IL1B / P01584 / interleukin 1 beta  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000115008 IL1A / P01583 / interleukin 1 alpha  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000115594 IL1R1 / P14778 / interleukin 1 receptor type 1  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction






 

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