ENSG00000196083


Homo sapiens

Features
Gene ID: ENSG00000196083
  
Biological name :IL1RAP
  
Synonyms : IL1RAP / interleukin 1 receptor accessory protein / Q9NPH3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q28
Gene start: 190514051
Gene end: 190659750
  
Corresponding Affymetrix probe sets: 205227_at (Human Genome U133 Plus 2.0 Array)   210233_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409352
Ensembl peptide - ENSP00000416296
Ensembl peptide - ENSP00000414102
Ensembl peptide - ENSP00000412053
Ensembl peptide - ENSP00000412008
Ensembl peptide - ENSP00000072516
Ensembl peptide - ENSP00000314807
Ensembl peptide - ENSP00000345829
Ensembl peptide - ENSP00000387371
Ensembl peptide - ENSP00000389149
Ensembl peptide - ENSP00000390541
Ensembl peptide - ENSP00000391899
Ensembl peptide - ENSP00000401132
Ensembl peptide - ENSP00000408893
NCBI entrez gene - 3556     See in Manteia.
OMIM - 602626
RefSeq - XM_017006348
RefSeq - NM_001167928
RefSeq - NM_001167929
RefSeq - NM_001167930
RefSeq - NM_001167931
RefSeq - NM_002182
RefSeq - NM_134470
RefSeq - XM_017006347
RefSeq Peptide - NP_001161400
RefSeq Peptide - NP_001161402
RefSeq Peptide - NP_001161403
RefSeq Peptide - NP_002173
RefSeq Peptide - NP_608273
RefSeq Peptide - NP_001161401
swissprot - C9J9W1
swissprot - C9JT28
swissprot - C9J1D9
swissprot - Q9NPH3
swissprot - H7C3W4
Ensembl - ENSG00000196083
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068246.1ENSDARG00000114719Danio rerio
 IL1RAPENSGALG00000007253Gallus gallus
 Il1rapENSMUSG00000022514Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NP60 / IL1RAPL2 / interleukin 1 receptor accessory protein like 2ENSG0000018910830
Q9NZN1 / IL1RAPL1 / interleukin 1 receptor accessory protein like 1ENSG0000016930629
O95256 / IL18RAP / interleukin 18 receptor accessory proteinENSG0000011560721
IL18R1 / Q13478 / interleukin 18 receptor 1ENSG0000011560420
IL1RL1 / Q01638 / interleukin 1 receptor like 1ENSG0000011560220
IL1R1 / P14778 / interleukin 1 receptor type 1ENSG0000011559418
IL1RL2 / Q9HB29 / interleukin 1 receptor like 2ENSG0000011559817
IL1R2 / P27930 / interleukin 1 receptor type 2ENSG0000011559011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032736 positive regulation of interleukin-13 production IEA
 biological_processGO:0032754 positive regulation of interleukin-5 production IEA
 biological_processGO:0038172 interleukin-33-mediated signaling pathway TAS
 biological_processGO:0042094 interleukin-2 biosynthetic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0072602 interleukin-4 secretion IEA
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002114 interleukin-33 receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078902 Q9H0E2 / TOLLIP / toll interacting protein  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000115602 IL1RL1 / Q01638 / interleukin 1 receptor like 1  / reaction / complex
 ENSG00000125538 IL1B / P01584 / interleukin 1 beta  / complex / reaction
 ENSG00000136694 IL36A / Q9UHA7 / interleukin 36 alpha  / reaction / complex
 ENSG00000115598 IL1RL2 / Q9HB29 / interleukin 1 receptor like 2  / reaction / complex
 ENSG00000136688 IL36G / Q9NZH8 / interleukin 36 gamma  / complex / reaction
 ENSG00000136696 IL36B / Q9NZH7 / interleukin 36 beta  / complex / reaction
 ENSG00000115008 IL1A / P01583 / interleukin 1 alpha  / complex / reaction
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / complex / reaction
 ENSG00000137033 IL33 / O95760 / interleukin 33  / complex / reaction
 ENSG00000115594 IL1R1 / P14778 / interleukin 1 receptor type 1  / reaction / complex






 

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