ENSG00000137033


Homo sapiens

Features
Gene ID: ENSG00000137033
  
Biological name :IL33
  
Synonyms : IL33 / interleukin 33 / O95760
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p24.1
Gene start: 6215786
Gene end: 6257983
  
Corresponding Affymetrix probe sets: 209821_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478858
Ensembl peptide - ENSP00000370842
Ensembl peptide - ENSP00000394039
Ensembl peptide - ENSP00000414238
NCBI entrez gene - 90865     See in Manteia.
OMIM - 608678
RefSeq - NM_001314047
RefSeq - NM_001314048
RefSeq - NM_001353802
RefSeq - NM_033439
RefSeq - XM_017015285
RefSeq - NM_001199640
RefSeq - NM_001199641
RefSeq - NM_001314044
RefSeq - NM_001314045
RefSeq - NM_001314046
RefSeq - XM_011518061
RefSeq Peptide - NP_001186570
RefSeq Peptide - NP_001300974
RefSeq Peptide - NP_001300975
RefSeq Peptide - NP_001300976
RefSeq Peptide - NP_001300977
RefSeq Peptide - NP_001340731
RefSeq Peptide - NP_254274
RefSeq Peptide - NP_001300973
RefSeq Peptide - NP_001186569
swissprot - O95760
Ensembl - ENSG00000137033
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il33ENSMUSG00000024810Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026145  Interleukin-33


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0002282 microglial cell activation involved in immune response IEA
 biological_processGO:0002686 negative regulation of leukocyte migration IEA
 biological_processGO:0002826 negative regulation of T-helper 1 type immune response IEA
 biological_processGO:0002830 positive regulation of type 2 immune response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032736 positive regulation of interleukin-13 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0032754 positive regulation of interleukin-5 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0038172 interleukin-33-mediated signaling pathway TAS
 biological_processGO:0042092 type 2 immune response IBA
 biological_processGO:0043032 positive regulation of macrophage activation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050729 positive regulation of inflammatory response IBA
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IEA
 biological_processGO:0051025 negative regulation of immunoglobulin secretion IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0061518 microglial cell proliferation IEA
 biological_processGO:0090197 positive regulation of chemokine secretion IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Ub-specific processing proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115602 IL1RL1 / Q01638 / interleukin 1 receptor like 1  / complex / reaction
 ENSG00000143258 USP21 / Q9UK80 / ubiquitin specific peptidase 21  / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex






 

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