ENSMUSG00000022514


Mus musculus

Features
Gene ID: ENSMUSG00000022514
  
Biological name :Il1rap
  
Synonyms : Il1rap / Interleukin-1 receptor accessory protein / Q61730
  
Possible biological names infered from orthology : Q9NPH3
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B2
Gene start: 26581704
Gene end: 26730117
  
Corresponding Affymetrix probe sets: 10434845 (MoGene1.0st)   1421843_at (Mouse Genome 430 2.0 Array)   1421844_at (Mouse Genome 430 2.0 Array)   1439697_at (Mouse Genome 430 2.0 Array)   1442614_at (Mouse Genome 430 2.0 Array)   1449585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093843
Ensembl peptide - ENSMUSP00000133904
Ensembl peptide - ENSMUSP00000023156
Ensembl peptide - ENSMUSP00000134202
Ensembl peptide - ENSMUSP00000128100
Ensembl peptide - ENSMUSP00000133294
NCBI entrez gene - 16180     See in Manteia.
MGI - MGI:104975
RefSeq - NM_001159318
RefSeq - NM_008364
RefSeq - NM_134103
RefSeq - NM_001159317
RefSeq Peptide - NP_001152789
RefSeq Peptide - NP_032390
RefSeq Peptide - NP_598864
RefSeq Peptide - NP_001152790
swissprot - Q61730
swissprot - G3XA78
swissprot - E9Q6I2
swissprot - Q3UEL3
swissprot - G3UY13
Ensembl - ENSMUSG00000022514
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068246.1ENSDARG00000114719Danio rerio
 IL1RAPENSGALG00000007253Gallus gallus
 IL1RAPENSG00000196083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*ENSMUSG0000005920331
Il1rapl1 / interleukin 1 receptor accessory protein like 1 / Q9NZN1*ENSMUSG0000005237228
Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*ENSMUSG0000002606921
Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*ENSMUSG0000002606820
Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*ENSMUSG0000002607219
Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*ENSMUSG0000007094219
Il18r1 / Q61098 / Interleukin-18 receptor 1 / Q13478*ENSMUSG0000002607018
Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*ENSMUSG0000002607312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0032736 positive regulation of interleukin-13 production IMP
 biological_processGO:0032754 positive regulation of interleukin-5 production IMP
 biological_processGO:0038172 interleukin-33-mediated signaling pathway IMP
 biological_processGO:0042094 interleukin-2 biosynthetic process IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0072602 interleukin-4 secretion IMP
 biological_processGO:1900006 positive regulation of dendrite development IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002114 interleukin-33 receptor activity IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IDA
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Receptor-type tyrosine-protein phosphatases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-36 pathway
Interleukin-33 signaling
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Irak1tm1Jth/Y
Genetic Background: B6.Cg-Irak1tm1Jth

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025139 Q9QZ06 / Tollip / toll interacting protein / Q9H0E2*  / complex / reaction
 ENSMUSG00000026072 Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*  / reaction / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex / reaction
 ENSMUSG00000024810 Il33 / Q8BVZ5 / Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266) / O95760* / interleukin 33*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000026069 Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / reaction / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / complex / reaction
 ENSMUSG00000026984 Il1f6 / Q9JLA2 / interleukin 1 family, member 6 / IL36A* / Q9UHA7* / interleukin 36 alpha*  / reaction / complex
 ENSMUSG00000026985 Il1f8 / Q9D6Z6 / Interleukin-36 beta / IL36B* / Q9NZH7*  / reaction / complex
 ENSMUSG00000027399 Il1a / P01582 / Interleukin-1 alpha / P01583*  / reaction / complex
 ENSMUSG00000044103 Il1f9 / IL36G* / Q9NZH8* / interleukin 36 gamma*  / reaction / complex
 ENSMUSG00000028399 Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*  / complex / reaction
 ENSMUSG00000070942 Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*  / reaction / complex






 

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