ENSMUSG00000026073


Mus musculus

Features
Gene ID: ENSMUSG00000026073
  
Biological name :Il1r2
  
Synonyms : Il1r2 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27931
  
Possible biological names infered from orthology : interleukin 1 receptor type 2 / P27930
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 40074079
Gene end: 40125231
  
Corresponding Affymetrix probe sets: 10345752 (MoGene1.0st)   1419532_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141882
Ensembl peptide - ENSMUSP00000027243
Ensembl peptide - ENSMUSP00000141785
Ensembl peptide - ENSMUSP00000141804
NCBI entrez gene - 16178     See in Manteia.
MGI - MGI:96546
RefSeq - XM_017317722
RefSeq - XM_006495726
RefSeq - XM_011238437
RefSeq - XM_011238438
RefSeq - XM_011238439
RefSeq - XM_011238440
RefSeq - NM_010555
RefSeq - XM_006495725
RefSeq Peptide - NP_034685
swissprot - A0A0A6YX83
swissprot - A0A0A6YX23
swissprot - P27931
swissprot - Q4FK69
Ensembl - ENSMUSG00000026073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01078737.1ENSDARG00000100461Danio rerio
 IL1R2ENSGALG00000046326Gallus gallus
 IL1R2ENSG00000115590Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*ENSMUSG0000002607224
Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*ENSMUSG0000007094223
Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*ENSMUSG0000005920322
Il1rapl1 / interleukin 1 receptor accessory protein like 1 / Q9NZN1*ENSMUSG0000005237221
Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*ENSMUSG0000002606920
Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*ENSMUSG0000002251420
Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*ENSMUSG0000002606819
Il18r1 / Q61098 / Interleukin-18 receptor 1 / Q13478*ENSMUSG0000002607016


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR004077  Interleukin-1 receptor type II
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010955 negative regulation of protein processing IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0050712 negative regulation of interleukin-1 alpha secretion IMP
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
 biological_processGO:2000660 negative regulation of interleukin-1-mediated signaling pathway IPI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004908 interleukin-1 receptor activity IPI
 molecular_functionGO:0004910 interleukin-1, type II, blocking receptor activity IEA
 molecular_functionGO:0019966 interleukin-1 binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027399 Il1a / P01582 / Interleukin-1 alpha / P01583*  / reaction / complex
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / reaction / complex
 ENSMUSG00000026981 Il1rn / P25085 / Interleukin-1 receptor antagonist protein / P18510* / interleukin 1 receptor antagonist*  / complex / reaction






 

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