ENSMUSG00000070942


Mus musculus

Features
Gene ID: ENSMUSG00000070942
  
Biological name :Il1rl2
  
Synonyms : Il1rl2 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9ERS7
  
Possible biological names infered from orthology : interleukin 1 receptor like 2 / Q9HB29
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 40324610
Gene end: 40367562
  
Corresponding Affymetrix probe sets: 10345777 (MoGene1.0st)   1434903_s_at (Mouse Genome 430 2.0 Array)   1450273_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092630
Ensembl peptide - ENSMUSP00000141507
Ensembl peptide - ENSMUSP00000142248
NCBI entrez gene - 107527     See in Manteia.
MGI - MGI:1913107
RefSeq - XM_006495611
RefSeq - NM_001356478
RefSeq - NM_133193
RefSeq - XM_006495608
RefSeq - XM_006495609
RefSeq - XM_006495610
RefSeq Peptide - NP_001343407
RefSeq Peptide - NP_573456
swissprot - Q9ERS7
swissprot - A0A0A6YWD7
swissprot - Q149G7
Ensembl - ENSMUSG00000070942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01054965.1ENSDARG00000090844Danio rerio
 CU855885.1ENSDARG00000101527Danio rerio
 IL1RL2ENSG00000115598Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*ENSMUSG0000002607236
Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*ENSMUSG0000002606925
Il1rapl1 / interleukin 1 receptor accessory protein like 1 / Q9NZN1*ENSMUSG0000005237224
Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*ENSMUSG0000005920323
Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*ENSMUSG0000002251422
Il18r1 / Q61098 / Interleukin-18 receptor 1 / Q13478*ENSMUSG0000002607020
Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*ENSMUSG0000002606820
Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*ENSMUSG0000002607316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR004076  Interleukin-1 receptor type 1
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IGI
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity ISS
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0004909 interleukin-1, type I, activating receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-38 signaling
Interleukin-36 pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026983 Il1f5 / Q9QYY1 / Interleukin-36 receptor antagonist protein / Q9UBH0* / IL36RN* / interleukin 36 receptor antagonist*  / reaction / complex
 ENSMUSG00000046845 Il1f10 / Q8R459 / Interleukin-1 family member 10 / Q8WWZ1*  / complex / reaction
 ENSMUSG00000026984 Il1f6 / Q9JLA2 / interleukin 1 family, member 6 / IL36A* / Q9UHA7* / interleukin 36 alpha*  / complex / reaction
 ENSMUSG00000026985 Il1f8 / Q9D6Z6 / Interleukin-36 beta / IL36B* / Q9NZH7*  / complex / reaction
 ENSMUSG00000044103 Il1f9 / IL36G* / Q9NZH8* / interleukin 36 gamma*  / reaction / complex
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / complex / reaction






 

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