ENSMUSG00000026981


Mus musculus

Features
Gene ID: ENSMUSG00000026981
  
Biological name :Il1rn
  
Synonyms : Il1rn / Interleukin-1 receptor antagonist protein / P25085
  
Possible biological names infered from orthology : interleukin 1 receptor antagonist / P18510
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 24336853
Gene end: 24351494
  
Corresponding Affymetrix probe sets: 10469816 (MoGene1.0st)   1423017_a_at (Mouse Genome 430 2.0 Array)   1425663_at (Mouse Genome 430 2.0 Array)   1451798_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110126
Ensembl peptide - ENSMUSP00000110129
Ensembl peptide - ENSMUSP00000110131
Ensembl peptide - ENSMUSP00000141269
NCBI entrez gene - 16181     See in Manteia.
MGI - MGI:96547
RefSeq - XM_006497727
RefSeq - NM_001039701
RefSeq - NM_001159562
RefSeq - NM_031167
RefSeq Peptide - NP_001034790
RefSeq Peptide - NP_001153034
RefSeq Peptide - NP_112444
swissprot - P25085
swissprot - Q3TBV5
swissprot - Q542C7
swissprot - Q542W1
swissprot - A0A0A6YVU4
Ensembl - ENSMUSG00000026981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL1RNENSG00000136689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il1f5 / Q9QYY1 / Interleukin-36 receptor antagonist protein / Q9UBH0* / IL36RN* / interleukin 36 receptor antagonist*ENSMUSG0000002698340
Il1f10 / Q8R459 / Interleukin-1 family member 10 / Q8WWZ1*ENSMUSG0000004684534


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR003297  Interleukin-1 receptor antagonist/Interleukin-36
 IPR008996  Cytokine IL1/FGF
 IPR020877  Interleukin-1 conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001660 fever generation IBA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006953 acute-phase response ISO
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:2000660 negative regulation of interleukin-1-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031982 vesicle IDA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005149 interleukin-1 receptor binding IBA
 molecular_functionGO:0005150 interleukin-1, type I receptor binding IEA
 molecular_functionGO:0005151 interleukin-1, type II receptor binding IEA
 molecular_functionGO:0005152 interleukin-1 receptor antagonist activity IEA
 molecular_functionGO:0045352 interleukin-1 type I receptor antagonist activity IEA
 molecular_functionGO:0045353 interleukin-1 type II receptor antagonist activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0001230 epidermal desquamation "shedding of the cuticle of the epidermis in scales or shreds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: B6.129-Il1rntm1Yiw

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002433 abnormal T helper 1 morphology/development "anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses. These cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002434 abnormal T helper 2 morphology/development "anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Il1rntm1Yiw/Il1rntm1Yiw,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: BALB/cAnNHsd * C57BL/6

Allelic Composition: Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: C.129-Il1rntm1Yiw

Allelic Composition: Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: B6.C3-Spta1sph/BrkJ

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: B6.129-Il1rntm1Yiw

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1rntm1Nick/Il1rn+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: BALB/cAnNHsd

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Zbtb7bhd/Zbtb7bhd
Genetic Background: involves: B6.129S2-Cd8atm1Mak * B6.Cg-Thpokhd

Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spta1sph/Spta1sph
Genetic Background: B6.C3-Spta1sph/BrkJ

 MP:0006135 arterial stenosis "abnormal narrowing of the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0008125 abnormal dendritic cell number "anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0008592 decreased circulating interleukin-1 level "reduction in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: C.129-Il1rntm1Yiw

Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Ted/Pdx1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0010139 aortitis "inflammation of the aorta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx2tm1Cim/Cbx2tm1Cim
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il1rntm1Nick/Il1rn+
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: 129P2/OlaHsd * MF1 * BALB/cAnNHsd

Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: BALB/cAnNHsd

Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: BALB/cAnNHsd * C57BL/6

 MP:0010214 abnormal circulating serum amyloid protein level "deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026073 Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*  / complex / reaction
 ENSMUSG00000026072 Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*  / complex / reaction






 

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