ENSG00000185187


Homo sapiens

Features
Gene ID: ENSG00000185187
  
Biological name :SIGIRR
  
Synonyms : Q6IA17 / SIGIRR / single Ig and TIR domain containing
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 405716
Gene end: 417455
  
Corresponding Affymetrix probe sets: 218921_at (Human Genome U133 Plus 2.0 Array)   52940_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433022
Ensembl peptide - ENSP00000431698
Ensembl peptide - ENSP00000433530
Ensembl peptide - ENSP00000435135
Ensembl peptide - ENSP00000434164
Ensembl peptide - ENSP00000434030
Ensembl peptide - ENSP00000333656
Ensembl peptide - ENSP00000380756
Ensembl peptide - ENSP00000403104
NCBI entrez gene - 59307     See in Manteia.
OMIM - 605478
RefSeq - XM_017018100
RefSeq - NM_001135053
RefSeq - NM_001135054
RefSeq - NM_021805
RefSeq - XM_005253044
RefSeq - XM_005253045
RefSeq - XM_005253046
RefSeq - XM_005253048
RefSeq - XM_017018099
RefSeq Peptide - NP_068577
RefSeq Peptide - NP_001128526
RefSeq Peptide - NP_001128525
swissprot - E9PK23
swissprot - H0YDF8
swissprot - H0YDR5
swissprot - Q6IA17
swissprot - C9JFX4
swissprot - E9PSD9
swissprot - E9PLG6
Ensembl - ENSG00000185187
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sigirrENSDARG00000062204Danio rerio
 SIGIRRENSGALG00000004267Gallus gallus
 Q9JLZ8ENSMUSG00000025494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001960 negative regulation of cytokine-mediated signaling pathway ISS
 biological_processGO:0006953 acute-phase response ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway TAS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0045079 negative regulation of chemokine biosynthetic process ISS
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
MyD88:Mal cascade initiated on plasma membrane
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115604 IL18R1 / Q13478 / interleukin 18 receptor 1  / complex / reaction
 ENSG00000125571 IL37 / Q9NZH6 / interleukin 37  / reaction / complex






 

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