ENSMUSG00000025494


Mus musculus

Features
Gene ID: ENSMUSG00000025494
  
Biological name :Sigirr
  
Synonyms : Q9JLZ8 / Sigirr / single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
  
Possible biological names infered from orthology : Q6IA17 / single Ig and TIR domain containing
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141091175
Gene end: 141100572
  
Corresponding Affymetrix probe sets: 10569024 (MoGene1.0st)   1449163_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147541
Ensembl peptide - ENSMUSP00000147444
Ensembl peptide - ENSMUSP00000147730
Ensembl peptide - ENSMUSP00000147853
Ensembl peptide - ENSMUSP00000095571
Ensembl peptide - ENSMUSP00000147280
NCBI entrez gene - 24058     See in Manteia.
MGI - MGI:1344402
RefSeq - XM_011249842
RefSeq - NM_023059
RefSeq - XM_006536175
RefSeq - XM_006536176
RefSeq - XM_006536177
RefSeq - XM_006536178
RefSeq - XM_006536179
RefSeq - XM_006536180
RefSeq - NM_001355055
RefSeq Peptide - NP_075546
RefSeq Peptide - NP_001341984
swissprot - Q9JLZ8
swissprot - A0A1B0GS99
swissprot - Q3UKS3
swissprot - A0A1B0GRA6
swissprot - A0A1B0GRZ7
Ensembl - ENSMUSG00000025494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sigirrENSDARG00000062204Danio rerio
 SIGIRRENSGALG00000004267Gallus gallus
 Q6IA17ENSG00000185187Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001960 negative regulation of cytokine-mediated signaling pathway IMP
 biological_processGO:0006953 acute-phase response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0045079 negative regulation of chemokine biosynthetic process IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2tm1Ykf
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sigirrtm1Mant/Sigirrtm1Mant
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009334 abnormal splenocyte proliferation "anomaly in the ability of a splenocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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