ENSG00000125571


Homo sapiens

Features
Gene ID: ENSG00000125571
  
Biological name :IL37
  
Synonyms : IL37 / interleukin 37 / Q9NZH6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.1
Gene start: 112912971
Gene end: 112918882
  
Corresponding Affymetrix probe sets: 221470_s_at (Human Genome U133 Plus 2.0 Array)   224555_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263328
Ensembl peptide - ENSP00000263326
Ensembl peptide - ENSP00000263327
Ensembl peptide - ENSP00000309208
Ensembl peptide - ENSP00000309883
NCBI entrez gene - 27178     See in Manteia.
OMIM - 605510
RefSeq - XM_011510964
RefSeq - NM_014439
RefSeq - NM_173202
RefSeq - NM_173203
RefSeq - NM_173204
RefSeq - NM_173205
RefSeq - XM_011510963
RefSeq Peptide - NP_775295
RefSeq Peptide - NP_775296
RefSeq Peptide - NP_775297
RefSeq Peptide - NP_055254
RefSeq Peptide - NP_775294
swissprot - Q9NZH6
Ensembl - ENSG00000125571
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL36G / Q9NZH8 / interleukin 36 gammaENSG0000013668824
IL36A / Q9UHA7 / interleukin 36 alphaENSG0000013669424
IL36B / Q9NZH7 / interleukin 36 betaENSG0000013669615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR003297  Interleukin-1 receptor antagonist/Interleukin-36
 IPR008996  Cytokine IL1/FGF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005149 interleukin-1 receptor binding TAS


Pathways (from Reactome)
Pathway description
Interleukin-37 signaling
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125571 IL37 / Q9NZH6 / interleukin 37  / complex
 ENSG00000137496 IL18BP / O95998 / interleukin 18 binding protein  / reaction / complex
 ENSG00000115604 IL18R1 / Q13478 / interleukin 18 receptor 1  / complex / reaction
 ENSG00000185187 Q6IA17 / SIGIRR / single Ig and TIR domain containing  / reaction / complex
 ENSG00000137752 CASP1 / P29466 / caspase 1  / complex
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction






 

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