ENSG00000103490


Homo sapiens

Features
Gene ID: ENSG00000103490
  
Biological name :PYCARD
  
Synonyms : PYCARD / PYD and CARD domain containing / Q9ULZ3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p11.2
Gene start: 31201485
Gene end: 31203450
  
Corresponding Affymetrix probe sets: 221666_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340441
Ensembl peptide - ENSP00000247470
Ensembl peptide - ENSP00000455141
NCBI entrez gene - 29108     See in Manteia.
OMIM - 606838
RefSeq - NM_145182
RefSeq - NM_013258
RefSeq Peptide - NP_037390
RefSeq Peptide - NP_660183
swissprot - Q9ULZ3
swissprot - H3BP42
Ensembl - ENSG00000103490
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pycardENSDARG00000040076Danio rerio
 PycardENSMUSG00000030793Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PYDC1 / Q8WXC3 / pyrin domain containing 1ENSG0000016990029


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR004020  DAPIN domain
 IPR011029  Death-like domain superfamily
 IPR033516  CARD8/ASC/NALP1, CARD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001773 myeloid dendritic cell activation IMP
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002277 myeloid dendritic cell activation involved in immune response ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II ISS
 biological_processGO:0002821 positive regulation of adaptive immune response IMP
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process NAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0031647 regulation of protein stability ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032688 negative regulation of interferon-beta production IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production ISS
 biological_processGO:0032755 positive regulation of interleukin-6 production ISS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0042104 positive regulation of activated T cell proliferation ISS
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044351 macropinocytosis ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0050766 positive regulation of phagocytosis ISS
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IPI
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IDA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:0090197 positive regulation of chemokine secretion IMP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:2000406 positive regulation of T cell migration ISS
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity IDA
 biological_processGO:2001181 positive regulation of interleukin-10 secretion IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA
 biological_processGO:2001242 regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008385 IkappaB kinase complex TAS
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0072558 NLRP1 inflammasome complex IDA
 cellular_componentGO:0072559 NLRP3 inflammasome complex IDA
 cellular_componentGO:0097169 AIM2 inflammasome complex IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0005138 interleukin-6 receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005523 tropomyosin binding IPI
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process NAS
 molecular_functionGO:0017024 myosin I binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0032090 Pyrin domain binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0070700 BMP receptor binding IPI
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
CLEC7A/inflammasome pathway
Neutrophil degranulation
The NLRP3 inflammasome
The AIM2 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103313 MEFV / O15553 / MEFV, pyrin innate immunity regulator  / reaction / complex
 ENSG00000103490 PYCARD / Q9ULZ3 / PYD and CARD domain containing  / reaction / complex
 ENSG00000137752 CASP1 / P29466 / caspase 1  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000165416 SUGT1 / Q9Y2Z0 / SGT1 homolog, MIS12 kinetochore complex assembly cochaperone  / reaction / complex
 ENSG00000162711 NLRP3 / Q96P20 / NLR family pyrin domain containing 3  / complex / reaction
 ENSG00000172175 MALT1 / Q9UDY8 / MALT1 paracaspase  / complex / reaction
 ENSG00000142192 APP / P05067 / amyloid beta precursor protein  / complex / reaction
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / reaction / complex
 ENSG00000163568 AIM2 / O14862 / absent in melanoma 2  / reaction / complex






 

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