ENSMUSG00000022534


Mus musculus

Features
Gene ID: ENSMUSG00000022534
  
Biological name :Mefv
  
Synonyms : Mefv / Pyrin / Q9JJ26
  
Possible biological names infered from orthology : MEFV, pyrin innate immunity regulator / O15553
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 3707218
Gene end: 3718097
  
Corresponding Affymetrix probe sets: 10437243 (MoGene1.0st)   1460283_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023180
Ensembl peptide - ENSMUSP00000097795
Ensembl peptide - ENSMUSP00000154892
NCBI entrez gene - 54483     See in Manteia.
MGI - MGI:1859396
RefSeq - XM_011245950
RefSeq - NM_001161790
RefSeq - NM_001161791
RefSeq - NM_019453
RefSeq - XM_006522361
RefSeq Peptide - NP_062326
RefSeq Peptide - NP_001155262
RefSeq Peptide - NP_001155263
swissprot - Q32MT0
swissprot - Q32MT1
swissprot - Q9JJ26
Ensembl - ENSMUSG00000022534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEFVENSG00000103313Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62158 / Trim27 / Zinc finger protein RFP / P14373* / tripartite motif containing 27*ENSMUSG0000002132613
Q9WUH5 / Trim10 / Tripartite motif-containing protein 10 / Q9UDY6* / tripartite motif containing 10*ENSMUSG0000007340010
Q5NCC3 / Trim41 / E3 ubiquitin-protein ligase TRIM41 / Q8WV44* / tripartite motif containing 41*ENSMUSG0000004036510
Q99PN3 / Trim26 / Tripartite motif-containing protein 26 / Q12899* / tripartite motif containing 26*ENSMUSG0000002445710
Trim7 / Q923T7 / tripartite motif-containing 7 / Q9C029*ENSMUSG000000403509
Q8R0K2 / Trim31 / E3 ubiquitin-protein ligase TRIM31 / Q9BZY9* / tripartite motif containing 31*ENSMUSG000000580639
Q80X56 / Trim69 / E3 ubiquitin-protein ligase TRIM69 / Q86WT6* / tripartite motif containing 69*ENSMUSG000000333689
Q80V85 / Trim62 / E3 ubiquitin-protein ligase TRIM62 / Q9BVG3* / tripartite motif containing 62*ENSMUSG000000410008
Q1XH17 / Trim72 / Tripartite motif-containing protein 72 / Q6ZMU5* / tripartite motif containing 72*ENSMUSG000000428288
Trim15 / tripartite motif-containing 15 / Q9C019*ENSMUSG000000507478
Trim35 / tripartite motif-containing 35 / Q9UPQ4*ENSMUSG000000220438
Q810I2 / Trim50 / Mus musculus tripartite motif-containing 50 (Trim50), transcript variant 2, mRNA. / Q86UV7* / Q86XT4* / TRIM73* / TRIM74* / Q86UV6* / tripartite motif containing 50* / tri...ENSMUSG000000533888


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR004020  DAPIN domain
 IPR011029  Death-like domain superfamily
 IPR028841  Pyrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0010508 positive regulation of autophagy ISS
 biological_processGO:0032691 negative regulation of interleukin-1 beta production ISO
 biological_processGO:0032695 negative regulation of interleukin-12 production ISO
 biological_processGO:0034341 response to interferon-gamma ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050728 negative regulation of inflammatory response ISO
 biological_processGO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production ISO
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly ISO
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity ISO
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex ISS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mefvtm3.1(MEFV)Chae/Mefvtm3.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm3.1(MEFV)Chae

Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Mefvtm3.1(MEFV)Chae/Mefvtm3.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm3.1(MEFV)Chae

Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ifnb1tm1Tl/Ifnb1tm1Tl
Genetic Background: B6.129P2-Ifnb1tm1Tl

Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mefvtm3.1(MEFV)Chae/Mefvtm3.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm3.1(MEFV)Chae

Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mefvtm3.1(MEFV)Chae/Mefvtm3.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm3.1(MEFV)Chae

Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm6Chae/Mefvtm6Chae
Genetic Background: B6.129S6-Mefvtm6Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm6Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae/Mefvtm6Chae

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mefvtm3.1(MEFV)Chae/Mefvtm3.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm3.1(MEFV)Chae

Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifnb1tm1Tl/Ifnb1tm1Tl
Genetic Background: B6.129P2-Ifnb1tm1Tl

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mefvtm3.1(MEFV)Chae/Mefvtm3.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm3.1(MEFV)Chae

Allelic Composition: Mefvtm4.1(MEFV)Chae/Mefvtm4.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm4.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008654 increased interleukin-1 alpha secretion "increase in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Nlrp3tm1Tsc/Nlrp3tm1Tsc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mefvtm1Bhk/Mefvtm1Bhk
Genetic Background: 129S6/SvEvTac-Mefvtm1Bhk

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008684 increased interleukin-18 secretion "increase in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Mefvtm1Bhk/Mefvtm1Bhk
Genetic Background: 129S6/SvEvTac-Mefvtm1Bhk

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008697 decreased interleukin-3 secretion "reduction in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008711 increased interleukin-9 secretion "increase in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030793 Pycard / Q9EPB4 / PYD and CARD domain containing / PYDC1* / Q9ULZ3* / Q8WXC3* / pyrin domain containing 1*  / reaction / complex
 ENSMUSG00000022534 Mefv / Pyrin / Q9JJ26 / O15553* / MEFV, pyrin innate immunity regulator*  / complex
 ENSMUSG00000032322 Pstpip1 / proline-serine-threonine phosphatase interacting protein 1 / O43586*  / complex / reaction






 

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