ENSMUSG00000042828


Mus musculus

Features
Gene ID: ENSMUSG00000042828
  
Biological name :Trim72
  
Synonyms : Q1XH17 / Trim72 / Tripartite motif-containing protein 72
  
Possible biological names infered from orthology : Q6ZMU5 / tripartite motif containing 72
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 128003949
Gene end: 128011033
  
Corresponding Affymetrix probe sets: 10557855 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000079832
Ensembl peptide - ENSMUSP00000101855
NCBI entrez gene - 434246     See in Manteia.
MGI - MGI:3612190
RefSeq - XM_006508003
RefSeq - NM_001079932
RefSeq - XM_006508002
RefSeq Peptide - NP_001073401
swissprot - Q1XH17
Ensembl - ENSMUSG00000042828
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6ZMU5ENSG00000177238Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q810I2 / Trim50 / Mus musculus tripartite motif-containing 50 (Trim50), transcript variant 2, mRNA. / Q86UV7* / Q86XT4* / TRIM73* / TRIM74* / Q86UV6* / tripartite motif containing 50* / tri...ENSMUSG0000005338832
Trim7 / Q923T7 / tripartite motif-containing 7 / Q9C029*ENSMUSG0000004035026
Q62158 / Trim27 / Zinc finger protein RFP / P14373* / tripartite motif containing 27*ENSMUSG0000002132625
Q5NCC3 / Trim41 / E3 ubiquitin-protein ligase TRIM41 / Q8WV44* / tripartite motif containing 41*ENSMUSG0000004036524
Trim35 / tripartite motif-containing 35 / Q9UPQ4*ENSMUSG0000002204323
Q80V85 / Trim62 / E3 ubiquitin-protein ligase TRIM62 / Q9BVG3* / tripartite motif containing 62*ENSMUSG0000004100023
Q8R0K2 / Trim31 / E3 ubiquitin-protein ligase TRIM31 / Q9BZY9* / tripartite motif containing 31*ENSMUSG0000005806323
Q9WUH5 / Trim10 / Tripartite motif-containing protein 10 / Q9UDY6* / tripartite motif containing 10*ENSMUSG0000007340022
Q80X56 / Trim69 / E3 ubiquitin-protein ligase TRIM69 / Q86WT6* / tripartite motif containing 69*ENSMUSG0000003336822
Q99PN3 / Trim26 / Tripartite motif-containing protein 26 / Q12899* / tripartite motif containing 26*ENSMUSG0000002445721
Mefv / Pyrin / Q9JJ26 / O15553* / MEFV, pyrin innate immunity regulator*ENSMUSG0000002253414
Trim15 / tripartite motif-containing 15 / Q9C019*ENSMUSG0000005074712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR035038  Tripartite motif-containing protein 72


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001778 plasma membrane repair IMP
 biological_processGO:0003012 muscle system process IMP
 biological_processGO:0006887 exocytosis TAS
 biological_processGO:0006900 vesicle budding from membrane TAS
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0010832 negative regulation of myotube differentiation IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IGI
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IDA
 biological_processGO:0051260 protein homooligomerization IPI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IMP


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gucy1b1tm1.2Frb/Gucy1b1tm1.2Frb,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: B6.Cg-Gucy1b1tm1.2Frb Tg(Myh11-cre/ERT2)1Soff

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Trim72tm1Ygko/Trim72tm1Ygko
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032231 Anxa2 / P07356 / Annexin A2 / P07355*  / reaction / complex
 ENSMUSG00000024659 Anxa1 / P10107 / Annexin A1 / P04083*  / complex / reaction
 ENSMUSG00000033788 Dysf / Q9ESD7 / Dysferlin / O75923*  / complex / reaction
 ENSMUSG00000062694 Cav3 / P51637 / Caveolin-3 / P56539*  / complex / reaction
 ENSMUSG00000018340 Anxa6 / P14824 / Annexin A6 / P08133*  / reaction / complex






 

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