ENSMUSG00000053388


Mus musculus

Features
Gene ID: ENSMUSG00000053388
  
Biological name :Trim50
  
Synonyms : Mus musculus tripartite motif-containing 50 (Trim50), transcript variant 2, mRNA. / Q810I2 / Trim50
  
Possible biological names infered from orthology : Q86UV6 / Q86UV7 / Q86XT4 / TRIM73 / TRIM74 / tripartite motif containing 50 / tripartite motif containing 73 / tripartite motif containing 74
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 135353295
Gene end: 135368005
  
Corresponding Affymetrix probe sets: 10526339 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000066662
Ensembl peptide - ENSMUSP00000106811
NCBI entrez gene - 215061     See in Manteia.
MGI - MGI:2664992
RefSeq - XM_006504412
RefSeq - NM_001346745
RefSeq - NM_178240
RefSeq - XM_006504411
RefSeq Peptide - NP_839971
RefSeq Peptide - NP_001333674
swissprot - Q810I2
swissprot - E9PVV5
Ensembl - ENSMUSG00000053388
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000021696Gallus gallus
 Q86UV6ENSG00000155428Homo sapiens
 Q86UV7ENSG00000178809Homo sapiens
 Q86XT4ENSG00000146755Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q1XH17 / Trim72 / Tripartite motif-containing protein 72 / Q6ZMU5* / tripartite motif containing 72*ENSMUSG0000004282832
Trim7 / Q923T7 / tripartite motif-containing 7 / Q9C029*ENSMUSG0000004035030
Q62158 / Trim27 / Zinc finger protein RFP / P14373* / tripartite motif containing 27*ENSMUSG0000002132627
Q5NCC3 / Trim41 / E3 ubiquitin-protein ligase TRIM41 / Q8WV44* / tripartite motif containing 41*ENSMUSG0000004036527
Q80V85 / Trim62 / E3 ubiquitin-protein ligase TRIM62 / Q9BVG3* / tripartite motif containing 62*ENSMUSG0000004100025
Q80X56 / Trim69 / E3 ubiquitin-protein ligase TRIM69 / Q86WT6* / tripartite motif containing 69*ENSMUSG0000003336825
Trim35 / tripartite motif-containing 35 / Q9UPQ4*ENSMUSG0000002204324
Q9WUH5 / Trim10 / Tripartite motif-containing protein 10 / Q9UDY6* / tripartite motif containing 10*ENSMUSG0000007340024
Q8R0K2 / Trim31 / E3 ubiquitin-protein ligase TRIM31 / Q9BZY9* / tripartite motif containing 31*ENSMUSG0000005806323
Q99PN3 / Trim26 / Tripartite motif-containing protein 26 / Q12899* / tripartite motif containing 26*ENSMUSG0000002445722
Mefv / Pyrin / Q9JJ26 / O15553* / MEFV, pyrin innate immunity regulator*ENSMUSG0000002253413
Trim15 / tripartite motif-containing 15 / Q9C019*ENSMUSG0000005074711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0070201 regulation of establishment of protein localization IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016235 aggresome IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J

 MP:0008001 hypochlorhydria "reduced hydrochloric acid content of the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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