ENSMUSG00000041000


Mus musculus

Features
Gene ID: ENSMUSG00000041000
  
Biological name :Trim62
  
Synonyms : E3 ubiquitin-protein ligase TRIM62 / Q80V85 / Trim62
  
Possible biological names infered from orthology : Q9BVG3 / tripartite motif containing 62
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 128883580
Gene end: 128911328
  
Corresponding Affymetrix probe sets: 10508376 (MoGene1.0st)   1436806_at (Mouse Genome 430 2.0 Array)   1436807_x_at (Mouse Genome 430 2.0 Array)   1452650_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123646
Ensembl peptide - ENSMUSP00000039121
NCBI entrez gene - 67525     See in Manteia.
MGI - MGI:1914775
RefSeq - NM_178110
RefSeq - XM_006503322
RefSeq Peptide - NP_835211
swissprot - D6RJM1
swissprot - Q80V85
Ensembl - ENSMUSG00000041000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-193i15.2ENSDARG00000095536Danio rerio
 trim62ENSDARG00000060901Danio rerio
 TRIM62ENSGALG00000028437Gallus gallus
 Q9BVG3ENSG00000116525Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim7 / Q923T7 / tripartite motif-containing 7 / Q9C029*ENSMUSG0000004035029
Q80X56 / Trim69 / E3 ubiquitin-protein ligase TRIM69 / Q86WT6* / tripartite motif containing 69*ENSMUSG0000003336828
Q62158 / Trim27 / Zinc finger protein RFP / P14373* / tripartite motif containing 27*ENSMUSG0000002132628
Trim35 / tripartite motif-containing 35 / Q9UPQ4*ENSMUSG0000002204327
Q5NCC3 / Trim41 / E3 ubiquitin-protein ligase TRIM41 / Q8WV44* / tripartite motif containing 41*ENSMUSG0000004036527
Q810I2 / Trim50 / Mus musculus tripartite motif-containing 50 (Trim50), transcript variant 2, mRNA. / Q86UV7* / Q86XT4* / TRIM73* / TRIM74* / Q86UV6* / tripartite motif containing 50* / tri...ENSMUSG0000005338825
Q9WUH5 / Trim10 / Tripartite motif-containing protein 10 / Q9UDY6* / tripartite motif containing 10*ENSMUSG0000007340025
Q99PN3 / Trim26 / Tripartite motif-containing protein 26 / Q12899* / tripartite motif containing 26*ENSMUSG0000002445723
Q1XH17 / Trim72 / Tripartite motif-containing protein 72 / Q6ZMU5* / tripartite motif containing 72*ENSMUSG0000004282823
Q8R0K2 / Trim31 / E3 ubiquitin-protein ligase TRIM31 / Q9BZY9* / tripartite motif containing 31*ENSMUSG0000005806320
Mefv / Pyrin / Q9JJ26 / O15553* / MEFV, pyrin innate immunity regulator*ENSMUSG0000002253414
Trim15 / tripartite motif-containing 15 / Q9C019*ENSMUSG0000005074713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR035830  TRIM62, PRY/SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032897 negative regulation of viral transcription IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046596 regulation of viral entry into host cell IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:1902186 regulation of viral release from host cell IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009591 liver adenocarcinoma "malignant neoplasm of epithelial cells in the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010367 increased spindle cell carcinoma incidence "greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance" [PMID:19040765]
Show

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Smarcb1tm1Sho/Smarcb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * DBA/2J

Allelic Composition: Trim62tm1Akil/Trim62+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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