ENSMUSG00000021326


Mus musculus

Features
Gene ID: ENSMUSG00000021326
  
Biological name :Trim27
  
Synonyms : Q62158 / Trim27 / Zinc finger protein RFP
  
Possible biological names infered from orthology : P14373 / tripartite motif containing 27
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A2
Gene start: 21179445
Gene end: 21194724
  
Corresponding Affymetrix probe sets: 10403903 (MoGene1.0st)   1415815_at (Mouse Genome 430 2.0 Array)   1438376_s_at (Mouse Genome 430 2.0 Array)   1441051_at (Mouse Genome 430 2.0 Array)   1448101_s_at (Mouse Genome 430 2.0 Array)   1456375_x_at (Mouse Genome 430 2.0 Array)   1457051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152179
Ensembl peptide - ENSMUSP00000152730
Ensembl peptide - ENSMUSP00000152230
Ensembl peptide - ENSMUSP00000021761
Ensembl peptide - ENSMUSP00000115397
NCBI entrez gene - 19720     See in Manteia.
MGI - MGI:97904
RefSeq - XM_006516606
RefSeq - NM_009054
RefSeq Peptide - NP_033080
swissprot - A0A1Y7VJ13
swissprot - A0A1Y7VKW0
swissprot - Q62158
swissprot - F6U3T5
Ensembl - ENSMUSG00000021326
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P14373ENSG00000204713Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim7 / Q923T7 / tripartite motif-containing 7 / Q9C029*ENSMUSG0000004035038
Q5NCC3 / Trim41 / E3 ubiquitin-protein ligase TRIM41 / Q8WV44* / tripartite motif containing 41*ENSMUSG0000004036534
Q99PN3 / Trim26 / Tripartite motif-containing protein 26 / Q12899* / tripartite motif containing 26*ENSMUSG0000002445731
Q9WUH5 / Trim10 / Tripartite motif-containing protein 10 / Q9UDY6* / tripartite motif containing 10*ENSMUSG0000007340030
Q80X56 / Trim69 / E3 ubiquitin-protein ligase TRIM69 / Q86WT6* / tripartite motif containing 69*ENSMUSG0000003336827
Q80V85 / Trim62 / E3 ubiquitin-protein ligase TRIM62 / Q9BVG3* / tripartite motif containing 62*ENSMUSG0000004100026
Q810I2 / Trim50 / Mus musculus tripartite motif-containing 50 (Trim50), transcript variant 2, mRNA. / Q86UV7* / Q86XT4* / TRIM73* / TRIM74* / Q86UV6* / tripartite motif containing 50* / tri...ENSMUSG0000005338825
Trim35 / tripartite motif-containing 35 / Q9UPQ4*ENSMUSG0000002204325
Q1XH17 / Trim72 / Tripartite motif-containing protein 72 / Q6ZMU5* / tripartite motif containing 72*ENSMUSG0000004282824
Q8R0K2 / Trim31 / E3 ubiquitin-protein ligase TRIM31 / Q9BZY9* / tripartite motif containing 31*ENSMUSG0000005806324
Mefv / Pyrin / Q9JJ26 / O15553* / MEFV, pyrin innate immunity regulator*ENSMUSG0000002253420
Trim15 / tripartite motif-containing 15 / Q9C019*ENSMUSG0000005074717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR020457  Zinc finger, B-box, chordata
 IPR035791  TRIM27, PRY/SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0002820 negative regulation of adaptive immune response ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0032720 negative regulation of tumor necrosis factor production ISS
 biological_processGO:0032897 negative regulation of viral transcription ISO
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation ISO
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISS
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045814 negative regulation of gene expression, epigenetic ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051127 positive regulation of actin nucleation IGI
 biological_processGO:0070206 protein trimerization ISO
 biological_processGO:0070534 protein K63-linked ubiquitination ISO
 biological_processGO:0072643 interferon-gamma secretion ISS
 biological_processGO:0090281 negative regulation of calcium ion import ISS
 biological_processGO:1900041 negative regulation of interleukin-2 secretion ISS
 biological_processGO:1902187 negative regulation of viral release from host cell IDA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030904 retromer complex ISS
 cellular_componentGO:0031965 nuclear membrane ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
SUMOylation of ubiquitinylation proteins
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tg(KRT14-Esr1/HRAS)1Pkha/0,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Smurf2Gt(RRA098)Byg/Smurf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smurf2Gt(RRA098)Byg/Smurf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ulk2tm1Thsn/Ulk2tm1Thsn
Genetic Background: B6.129-Ulk2tm1Thsn

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ulk2tm1Thsn/Ulk2tm1Thsn
Genetic Background: B6.129-Ulk2tm1Thsn

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smurf2Gt(RRA098)Byg/Smurf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tg(KRT14-Esr1/HRAS)1Pkha/0,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ulk2tm1Thsn/Ulk2tm1Thsn
Genetic Background: B6.129-Ulk2tm1Thsn

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ulk2tm1Thsn/Ulk2tm1Thsn
Genetic Background: B6.129-Ulk2tm1Thsn

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Tyj/Rb1+,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Tyj/Rb1+,Trim27Gt(XP0484)Wtsi/Trim27Gt(XP0484)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr