ENSMUSG00000018340


Mus musculus

Features
Gene ID: ENSMUSG00000018340
  
Biological name :Anxa6
  
Synonyms : Annexin A6 / Anxa6 / P14824
  
Possible biological names infered from orthology : P08133
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 54979108
Gene end: 55033445
  
Corresponding Affymetrix probe sets: 10385966 (MoGene1.0st)   1415818_at (Mouse Genome 430 2.0 Array)   1429246_a_at (Mouse Genome 430 2.0 Array)   1429247_at (Mouse Genome 430 2.0 Array)   1442288_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099788
Ensembl peptide - ENSMUSP00000104511
NCBI entrez gene - 11749     See in Manteia.
MGI - MGI:88255
RefSeq - NM_001110211
RefSeq - NM_013472
RefSeq Peptide - NP_001103681
RefSeq Peptide - NP_038500
swissprot - P14824
swissprot - F8WIT2
Ensembl - ENSMUSG00000018340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anxa6ENSDARG00000013335Danio rerio
 ANXA6ENSGALG00000004357Gallus gallus
 ANXA6ENSG00000197043Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Anxa5 / P48036 / Annexin A5 / P08758*ENSMUSG0000002771228
Anxa11 / P97384 / Annexin A11 / P50995*ENSMUSG0000002186627
Anxa4 / P97429 / Mus musculus annexin A4 (Anxa4), transcript variant 1, mRNA. / P09525* / annexin A4*ENSMUSG0000002999426
Anxa8 / O35640 / Annexin A8 / P13928* / Q5VT79* / ANXA8L1* / annexin A8 like 1*ENSMUSG0000002195025
Anxa3 / O35639 / Annexin A3 / P12429*ENSMUSG0000002948423
Anxa2 / P07356 / Annexin A2 / P07355*ENSMUSG0000003223122
Anxa1 / P10107 / Annexin A1 / P04083*ENSMUSG0000002465921
Anxa7 / Q07076 / Annexin A7 / P20073*ENSMUSG0000002181421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR002393  Annexin A6
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat
 IPR037104  Annexin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006937 regulation of muscle contraction IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IMP
 biological_processGO:0097190 apoptotic signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Dnd1Ter/Dnd1+
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1Mag,Tg(Lck-cre)1Cwi/?,Tg(LCKprBCL2)36Sjk/?
Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dnd1Ter/Dnd1+
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0013763 increased T-helper cell number "increase in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
Show

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024659 Anxa1 / P10107 / Annexin A1 / P04083*  / complex / reaction
 ENSMUSG00000033788 Dysf / Q9ESD7 / Dysferlin / O75923*  / complex / reaction
 ENSMUSG00000032231 Anxa2 / P07356 / Annexin A2 / P07355*  / complex / reaction
 ENSMUSG00000042828 Q1XH17 / Trim72 / Tripartite motif-containing protein 72 / Q6ZMU5* / tripartite motif containing 72*  / complex / reaction
 ENSMUSG00000062694 Cav3 / P51637 / Caveolin-3 / P56539*  / complex / reaction






 

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