ENSMUSG00000021814


Mus musculus

Features
Gene ID: ENSMUSG00000021814
  
Biological name :Anxa7
  
Synonyms : Annexin A7 / Anxa7 / Q07076
  
Possible biological names infered from orthology : P20073
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 20455260
Gene end: 20480133
  
Corresponding Affymetrix probe sets: 10417869 (MoGene1.0st)   1416137_at (Mouse Genome 430 2.0 Array)   1416138_at (Mouse Genome 430 2.0 Array)   1438764_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098405
Ensembl peptide - ENSMUSP00000153669
Ensembl peptide - ENSMUSP00000153174
Ensembl peptide - ENSMUSP00000153130
Ensembl peptide - ENSMUSP00000066035
NCBI entrez gene - 11750     See in Manteia.
MGI - MGI:88031
RefSeq - XM_006518453
RefSeq - NM_001110794
RefSeq - NM_009674
RefSeq - XM_006518452
RefSeq Peptide - NP_001104264
RefSeq Peptide - NP_033804
swissprot - A0A2C9F2D2
swissprot - A0A286YCS5
swissprot - A0A286YCW4
swissprot - Q07076
Ensembl - ENSMUSG00000021814
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ANXA7ENSGALG00000005299Gallus gallus
 ANXA7ENSG00000138279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Anxa11 / P97384 / Annexin A11 / P50995*ENSMUSG0000002186654
Anxa8 / O35640 / Annexin A8 / P13928* / Q5VT79* / ANXA8L1* / annexin A8 like 1*ENSMUSG0000002195034
Anxa4 / P97429 / Mus musculus annexin A4 (Anxa4), transcript variant 1, mRNA. / P09525* / annexin A4*ENSMUSG0000002999434
Anxa5 / P48036 / Annexin A5 / P08758*ENSMUSG0000002771232
Anxa2 / P07356 / Annexin A2 / P07355*ENSMUSG0000003223131
Anxa3 / O35639 / Annexin A3 / P12429*ENSMUSG0000002948431
Anxa1 / P10107 / Annexin A1 / P04083*ENSMUSG0000002465931
Anxa6 / P14824 / Annexin A6 / P08133*ENSMUSG0000001834030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR013286  Annexin A7
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat
 IPR034309  Annexin A7, chordates
 IPR037104  Annexin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0007599 hemostasis IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0009651 response to salt stress IMP
 biological_processGO:0009992 cellular water homeostasis IMP
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0061025 membrane fusion IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0042584 chromaffin granule membrane ISO
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thrbtm2Few/Thrb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001765 abnormal ion homeostasis "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thrbtm2Few/Thrb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Nkx3-1tm1Saa/Nkx3-1tm1Saa,Tg(KLK3-cre)13Saa/?
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Thrbtm2Few/Thrb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Anxa7tm1Pll/Anxa7+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr