ENSMUSG00000027712


Mus musculus

Features
Gene ID: ENSMUSG00000027712
  
Biological name :Anxa5
  
Synonyms : Annexin A5 / Anxa5 / P48036
  
Possible biological names infered from orthology : P08758
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 36448923
Gene end: 36475894
  
Corresponding Affymetrix probe sets: 10497817 (MoGene1.0st)   1425567_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143650
Ensembl peptide - ENSMUSP00000029266
NCBI entrez gene - 11747     See in Manteia.
MGI - MGI:106008
RefSeq - NM_009673
RefSeq Peptide - NP_033803
swissprot - A0A0G2JGQ0
swissprot - P48036
Ensembl - ENSMUSG00000027712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anxa5aENSDARG00000026406Danio rerio
 anxa5bENSDARG00000016470Danio rerio
 ANXA5ENSGALG00000011885Gallus gallus
 ANXA5ENSG00000164111Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Anxa6 / P14824 / Annexin A6 / P08133*ENSMUSG0000001834058
Anxa8 / O35640 / Annexin A8 / P13928* / Q5VT79* / ANXA8L1* / annexin A8 like 1*ENSMUSG0000002195055
Anxa4 / P97429 / Mus musculus annexin A4 (Anxa4), transcript variant 1, mRNA. / P09525* / annexin A4*ENSMUSG0000002999455
Anxa11 / P97384 / Annexin A11 / P50995*ENSMUSG0000002186654
Anxa3 / O35639 / Annexin A3 / P12429*ENSMUSG0000002948448
Anxa7 / Q07076 / Annexin A7 / P20073*ENSMUSG0000002181446
Anxa2 / P07356 / Annexin A2 / P07355*ENSMUSG0000003223144
Anxa1 / P10107 / Annexin A1 / P04083*ENSMUSG0000002465941


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR002392  Annexin A5
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat
 IPR037104  Annexin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0050819 negative regulation of coagulation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0072563 endothelial microparticle IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ciitatm1Adm/Ciita+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ciitatm1Adm/Ciita+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Dnd1Ter/Dnd1+
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Adm/Ciita+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dnd1Ter/Dnd1+
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0013763 increased T-helper cell number "increase in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
Show

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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