ENSMUSG00000032231


Mus musculus

Features
Gene ID: ENSMUSG00000032231
  
Biological name :Anxa2
  
Synonyms : Annexin A2 / Anxa2 / P07356
  
Possible biological names infered from orthology : P07355
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: C
Gene start: 69453620
Gene end: 69491795
  
Corresponding Affymetrix probe sets: 10586744 (MoGene1.0st)   1419091_a_at (Mouse Genome 430 2.0 Array)   1437691_at (Mouse Genome 430 2.0 Array)   1437692_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034756
Ensembl peptide - ENSMUSP00000122175
Ensembl peptide - ENSMUSP00000117979
Ensembl peptide - ENSMUSP00000117855
NCBI entrez gene - 12306     See in Manteia.
MGI - MGI:88246
RefSeq - XM_006510796
RefSeq - NM_007585
RefSeq Peptide - NP_031611
swissprot - B0V2N7
swissprot - B0V2N8
swissprot - P07356
swissprot - Q542G9
swissprot - B0V2N5
Ensembl - ENSMUSG00000032231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anxa2aENSDARG00000003216Danio rerio
 anxa2bENSDARG00000053625Danio rerio
 ANXA2ENSGALG00000003770Gallus gallus
 ANXA2ENSG00000182718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Anxa1 / P10107 / Annexin A1 / P04083*ENSMUSG0000002465952
Anxa4 / P97429 / Mus musculus annexin A4 (Anxa4), transcript variant 1, mRNA. / P09525* / annexin A4*ENSMUSG0000002999447
Anxa11 / P97384 / Annexin A11 / P50995*ENSMUSG0000002186645
Anxa6 / P14824 / Annexin A6 / P08133*ENSMUSG0000001834044
Anxa3 / O35639 / Annexin A3 / P12429*ENSMUSG0000002948444
Anxa8 / O35640 / Annexin A8 / P13928* / Q5VT79* / ANXA8L1* / annexin A8 like 1*ENSMUSG0000002195043
Anxa7 / Q07076 / Annexin A7 / P20073*ENSMUSG0000002181442
Anxa5 / P48036 / Annexin A5 / P08758*ENSMUSG0000002771242


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR002389  Annexin A2
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat
 IPR037104  Annexin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001765 membrane raft assembly IEA
 biological_processGO:0001921 positive regulation of receptor recycling IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006900 vesicle budding from membrane IEA
 biological_processGO:0007589 body fluid secretion IEA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0031340 positive regulation of vesicle fusion IEA
 biological_processGO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process IMP
 biological_processGO:0036035 osteoclast development IEA
 biological_processGO:0042730 fibrinolysis IMP
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0044090 positive regulation of vacuole organization IEA
 biological_processGO:0044147 negative regulation of development of symbiont involved in interaction with host IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051099 positive regulation of binding IMP
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0052362 catabolism by host of symbiont protein IEA
 biological_processGO:0052405 negative regulation by host of symbiont molecular function IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1905581 positive regulation of low-density lipoprotein particle clearance IMP
 biological_processGO:1905597 positive regulation of low-density lipoprotein particle receptor binding IMP
 biological_processGO:1905599 positive regulation of low-density lipoprotein receptor activity IMP
 biological_processGO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0035749 myelin sheath adaxonal region IDA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IDA
 cellular_componentGO:0044354 macropinosome IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:1990667 PCSK9-AnxA2 complex IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004859 phospholipase inhibitor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0019834 phospholipase A2 inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0044730 bone sialoprotein binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IEA
 molecular_functionGO:0098772 molecular function regulator IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

 MP:0020408 altered susceptibility to induced thrombosis "any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm1Snj/Trp53tm1Snj
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024659 Anxa1 / P10107 / Annexin A1 / P04083*  / complex / reaction
 ENSMUSG00000062694 Cav3 / P51637 / Caveolin-3 / P56539*  / complex / reaction
 ENSMUSG00000033788 Dysf / Q9ESD7 / Dysferlin / O75923*  / complex / reaction
 ENSMUSG00000042828 Q1XH17 / Trim72 / Tripartite motif-containing protein 72 / Q6ZMU5* / tripartite motif containing 72*  / complex / reaction
 ENSMUSG00000032231 Anxa2 / P07356 / Annexin A2 / P07355*  / complex
 ENSMUSG00000041959 P08207 / S100a10 / S100 calcium binding protein A10 (calpactin) / P60903* / S100 calcium binding protein A10*  / complex
 ENSMUSG00000018340 Anxa6 / P14824 / Annexin A6 / P08133*  / reaction / complex






 

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